Thymoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathologic Classification== | |||
====Thymic epithelial tumors can be divided according to the degree of differentiation into==== | |||
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|+ World Health Organization Histologic Classification<ref name="www.ncbi.nlm.nih.gov">{{Cite web | last = | first = | title = WHO histologic classification is a prognosti... [Ann Thorac Surg. 2004] - PubMed - NCBI | url = http://www.ncbi.nlm.nih.gov/pubmed/15063231 | publisher = | date = | accessdate = }}</ref> | |||
! Type | |||
! Description | |||
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| '''A''' || A tumor composed of a population of neoplastic thymic epithelial cells having spindle/oval shape, lacking nuclear atypia, and accompanied by few or no nonneoplastic lymphocytes. | |||
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| '''AB''' || A tumor in which foci having the features of type A thymoma are admixed with foci rich in lymphocytes. | |||
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| '''B1''' || A tumor that resembles the normal functional thymus in that it combines large expanses having an appearance practically indistinguishable from normal thymic cortex with areas resembling thymic medulla. | |||
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| '''B2''' || A tumor in which the neoplastic epithelial component appears as scattered plump cells with vesicular nuclei and distinct nucleoli among a heavy population of lymphocytes. Perivascular spaces are common and sometimes very prominent. A perivascular arrangement of tumor cells resulting in a palisading effect may be seen. | |||
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| '''B3''' || A type of thymoma predominantly composed of epithelial cells having a round or polygonal shape and exhibiting no or mild atypia. They are admixed with a mild component of lymphocytes, resulting in a sheetlike growth of the neoplastic epithelial cells. | |||
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| '''C''' || A thymic tumor (thymic carcinoma) exhibiting clear-cut cytologic atypia and a set of cytoarchitectural features no longer specific to the thymus, but rather analogous to those seen in carcinomas of other organs. Type C thymomas lack immature lymphocytes; whatever lymphocytes may be present are mature and usually admixed with plasma cells. | |||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 16:12, 21 September 2015
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Thymoma Microchapters |
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Diagnosis |
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Thymoma classification On the Web |
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American Roentgen Ray Society Images of Thymoma classification |
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Risk calculators and risk factors for Thymoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathologic Classification
Thymic epithelial tumors can be divided according to the degree of differentiation into
| Type | Description |
|---|---|
| A | A tumor composed of a population of neoplastic thymic epithelial cells having spindle/oval shape, lacking nuclear atypia, and accompanied by few or no nonneoplastic lymphocytes. |
| AB | A tumor in which foci having the features of type A thymoma are admixed with foci rich in lymphocytes. |
| B1 | A tumor that resembles the normal functional thymus in that it combines large expanses having an appearance practically indistinguishable from normal thymic cortex with areas resembling thymic medulla. |
| B2 | A tumor in which the neoplastic epithelial component appears as scattered plump cells with vesicular nuclei and distinct nucleoli among a heavy population of lymphocytes. Perivascular spaces are common and sometimes very prominent. A perivascular arrangement of tumor cells resulting in a palisading effect may be seen. |
| B3 | A type of thymoma predominantly composed of epithelial cells having a round or polygonal shape and exhibiting no or mild atypia. They are admixed with a mild component of lymphocytes, resulting in a sheetlike growth of the neoplastic epithelial cells. |
| C | A thymic tumor (thymic carcinoma) exhibiting clear-cut cytologic atypia and a set of cytoarchitectural features no longer specific to the thymus, but rather analogous to those seen in carcinomas of other organs. Type C thymomas lack immature lymphocytes; whatever lymphocytes may be present are mature and usually admixed with plasma cells. |