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__NOTOC__ | __NOTOC__ | ||
{{DRESS syndrome}} | {{DRESS syndrome}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{YD}}; {{SSK}} | ||
==Overview== | ==Overview== | ||
Other diagnostic studies for DRESS syndrome include elevated anti-HHV-6 IgG antibody, positive lymphocyte activation test, patch testing, and rechallenging of the suspected drug. | |||
==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Anti-HHV-6 Antibody=== | |||
*Herpes virus reactivation is common among patients with DRESS syndrome and may occur in approximately 80% of cases.<ref name="pmid21592453">{{cite journal| author=Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L et al.| title=The DRESS syndrome: a literature review. | journal=Am J Med | year= 2011 | volume= 124 | issue= 7 | pages= 588-97 | pmid=21592453 | doi=10.1016/j.amjmed.2011.01.017 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21592453 }} </ref> | |||
*Elevated anti-HHV-6 IgG antibody is thought to be a useful diagnostic test when DRESS syndrome is suspected.<ref name="pmid21592453">{{cite journal| author=Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L et al.| title=The DRESS syndrome: a literature review. | journal=Am J Med | year= 2011 | volume= 124 | issue= 7 | pages= 588-97 | pmid=21592453 | doi=10.1016/j.amjmed.2011.01.017 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21592453 }} </ref> | |||
===Lymphocyte Activation Test=== | |||
*The lymphocyte activation test is characterized by a low sensitivity and low specificity for DRESS syndrome.<ref name="pmid17983378">{{cite journal| author=Kano Y, Hirahara K, Mitsuyama Y, Takahashi R, Shiohara T| title=Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption. | journal=Allergy | year= 2007 | volume= 62 | issue= 12 | pages= 1439-44 | pmid=17983378 | doi=10.1111/j.1398-9995.2007.01553.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17983378 }} </ref> | |||
*The test may be falsely negative during the acute phase of DRESS syndrome.<ref name="pmid17983378">{{cite journal| author=Kano Y, Hirahara K, Mitsuyama Y, Takahashi R, Shiohara T| title=Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption. | journal=Allergy | year= 2007 | volume= 62 | issue= 12 | pages= 1439-44 | pmid=17983378 | doi=10.1111/j.1398-9995.2007.01553.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17983378 }} </ref> | |||
===Patch Testing=== | |||
*The diagnostic efficacy of patch testing is still controversial. | |||
*Patch testing has yielded variable results and is presumed to be effective only when the suspected triggering agent is an anticonvulsant.<ref name="pmid20136879">{{cite journal| author=Santiago F, Gonçalo M, Vieira R, Coelho S, Figueiredo A| title=Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS). | journal=Contact Dermatitis | year= 2010 | volume= 62 | issue= 1 | pages= 47-53 | pmid=20136879 | doi=10.1111/j.1600-0536.2009.01659.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20136879 }} </ref> The efficacy of patch testing requires further validation. | |||
===Rechallenge Suspected Drug=== | |||
*The approach has been used in other drug eruptions, but it has not been validated as a diagnostic strategy for DRESS syndrome given the potential life-threatening complications of the disease.<ref name="pmid23882307">{{cite journal| author=Choudhary S, McLeod M, Torchia D, Romanelli P| title=Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome. | journal=J Clin Aesthet Dermatol | year= 2013 | volume= 6 | issue= 6 | pages= 31-7 | pmid=23882307 | doi= | pmc=PMC3718748 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23882307 }} </ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:22, 21 September 2015
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DRESS syndrome Microchapters |
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DRESS syndrome On the Web |
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American Roentgen Ray Society Images of DRESS syndrome |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Serge Korjian M.D.
Overview
Other diagnostic studies for DRESS syndrome include elevated anti-HHV-6 IgG antibody, positive lymphocyte activation test, patch testing, and rechallenging of the suspected drug.
Other Diagnostic Studies
Anti-HHV-6 Antibody
- Herpes virus reactivation is common among patients with DRESS syndrome and may occur in approximately 80% of cases.[1]
- Elevated anti-HHV-6 IgG antibody is thought to be a useful diagnostic test when DRESS syndrome is suspected.[1]
Lymphocyte Activation Test
- The lymphocyte activation test is characterized by a low sensitivity and low specificity for DRESS syndrome.[2]
- The test may be falsely negative during the acute phase of DRESS syndrome.[2]
Patch Testing
- The diagnostic efficacy of patch testing is still controversial.
- Patch testing has yielded variable results and is presumed to be effective only when the suspected triggering agent is an anticonvulsant.[3] The efficacy of patch testing requires further validation.
Rechallenge Suspected Drug
- The approach has been used in other drug eruptions, but it has not been validated as a diagnostic strategy for DRESS syndrome given the potential life-threatening complications of the disease.[4]
References
- ↑ 1.0 1.1 Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L; et al. (2011). "The DRESS syndrome: a literature review". Am J Med. 124 (7): 588–97. doi:10.1016/j.amjmed.2011.01.017. PMID 21592453.
- ↑ 2.0 2.1 Kano Y, Hirahara K, Mitsuyama Y, Takahashi R, Shiohara T (2007). "Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption". Allergy. 62 (12): 1439–44. doi:10.1111/j.1398-9995.2007.01553.x. PMID 17983378.
- ↑ Santiago F, Gonçalo M, Vieira R, Coelho S, Figueiredo A (2010). "Epicutaneous patch testing in drug hypersensitivity syndrome (DRESS)". Contact Dermatitis. 62 (1): 47–53. doi:10.1111/j.1600-0536.2009.01659.x. PMID 20136879.
- ↑ Choudhary S, McLeod M, Torchia D, Romanelli P (2013). "Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome". J Clin Aesthet Dermatol. 6 (6): 31–7. PMC 3718748. PMID 23882307.