Angiomyolipoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathophysiology== | ==Pathophysiology== | ||
==Gross== | |||
*Well circumscribed - uniform yellow. | |||
Since all three components of an angiomyolipoma (vascular cells, immature [[smooth muscle cells]] and fat cells) contain a "second hit" mutation, they are believed to have derived from a common [[progenitor cell]] that suffered the common second hit mutation. [[Angiomyolipoma]]s are members of the perivascular epithelioid cells tumour group (PEComas) and are composed of variable amounts of three components;[[blood vessels]] (-angio), plump [[spindle cells]] (-myo) and [[adipose tissue]] (-lipo). Almost all classic angiomyolipomas are benign but they do have the risk of rupture with bleeding or secondary damage/destruction of surrounding structures as they grow. | Since all three components of an angiomyolipoma (vascular cells, immature [[smooth muscle cells]] and fat cells) contain a "second hit" mutation, they are believed to have derived from a common [[progenitor cell]] that suffered the common second hit mutation. [[Angiomyolipoma]]s are members of the perivascular epithelioid cells tumour group (PEComas) and are composed of variable amounts of three components;[[blood vessels]] (-angio), plump [[spindle cells]] (-myo) and [[adipose tissue]] (-lipo). Almost all classic angiomyolipomas are benign but they do have the risk of rupture with bleeding or secondary damage/destruction of surrounding structures as they grow. | ||
Revision as of 20:51, 21 September 2015
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Angiomyolipoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Angiomyolipoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Angiomyolipoma pathophysiology |
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Risk calculators and risk factors for Angiomyolipoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Faizan Sheraz, M.D. [3]
Overview
Pathophysiology
Gross
- Well circumscribed - uniform yellow.
Since all three components of an angiomyolipoma (vascular cells, immature smooth muscle cells and fat cells) contain a "second hit" mutation, they are believed to have derived from a common progenitor cell that suffered the common second hit mutation. Angiomyolipomas are members of the perivascular epithelioid cells tumour group (PEComas) and are composed of variable amounts of three components;blood vessels (-angio), plump spindle cells (-myo) and adipose tissue (-lipo). Almost all classic angiomyolipomas are benign but they do have the risk of rupture with bleeding or secondary damage/destruction of surrounding structures as they grow.
Variants
There is a special variant called an epithelioid angiomyolipoma, composed of more plump, epithelial looking cells, often with nuclear atypia, that have a described risk of malignant behaviour. This variant, unlike conventional AMLs, may mimic renal cell carcinoma.10 Metastases have also been described 9.
Microscopic Pathology
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