Thymoma natural history: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 15: | Line 15: | ||
* Thymomic malignancy of unknown etiology may arise | * Thymomic malignancy of unknown etiology may arise | ||
====Complications of Radiotherapy==== | ====Complications of Radiotherapy==== | ||
The most common complications | The most common complications of radiotherapy are: | ||
*[[Pulmonary fibrosis]] | *[[Pulmonary fibrosis]] | ||
*[[Pericarditis]] | *[[Pericarditis]] | ||
| Line 22: | Line 22: | ||
The new technique of radiotherapy will hopefully has less toxicity.<ref name="www.ncbi.nlm.nih.gov">{{Cite web | last = | first = | title = Technical advances of radiation therapy for t... [J Thorac Oncol. 2010] - PubMed - NCBI | url = http://www.ncbi.nlm.nih.gov/pubmed/20859129 | publisher = | date = | accessdate = }}</ref> | The new technique of radiotherapy will hopefully has less toxicity.<ref name="www.ncbi.nlm.nih.gov">{{Cite web | last = | first = | title = Technical advances of radiation therapy for t... [J Thorac Oncol. 2010] - PubMed - NCBI | url = http://www.ncbi.nlm.nih.gov/pubmed/20859129 | publisher = | date = | accessdate = }}</ref> | ||
====Complications of Surgery==== | ====Complications of Surgery==== | ||
*The complications of the procedure | The most common complications of [[thymectomy]] are: | ||
*The complications of the procedure such as bleeding, infection, damage to other organs, nerve injuries(biateral phrenic nerve injury) and respiratory failure. | |||
*Recurrence was described 10-20 years after removal of the primary lesion, so long term follow up is very important. | *Recurrence was described 10-20 years after removal of the primary lesion, so long term follow up is very important. | ||
*Live attenuated [[vaccines]] such as [[yellow fever]] vaccine may have adverse side effect after [[thymectomy]] due to inadequate T-cell response. | *Live attenuated [[vaccines]] such as [[yellow fever]] vaccine may have adverse side effect after [[thymectomy]] due to inadequate T-cell response. | ||
====Complications of Thymic Biopsy==== | ====Complications of Thymic Biopsy==== | ||
*[[Pneumothorax]] | The complications of the biopsy are: | ||
*[[Pneumothorax]] | |||
*[[Mediastinitis]] | |||
===Prognosis=== | ===Prognosis=== | ||
| Line 37: | Line 40: | ||
*Whether the tumor can be removed completely by surgery | *Whether the tumor can be removed completely by surgery | ||
*The patient's general health | *The patient's general health | ||
*Whether the cancer has just been diagnosed or has recurred | *Whether the cancer has just been diagnosed or has recurred. | ||
*The | *The prognostic factors for recurrence and survival are the stage at diagnosis and whether a complete resection has been achieved. | ||
*The | *The histologic types include lymphocyte predominant, epithelial predominant, and mixed. The mixed histologic type was associated with the worst prognosis. | ||
*the presence of myasthenia gravis at diagnosis is of less prognostic significance today.<ref name="www.ncbi.nlm.nih.gov">{{Cite web | last = | first = | title = A review of prognostic factors in thymic mali... [J Thorac Oncol. 2011] - PubMed - NCBI | url = http://www.ncbi.nlm.nih.gov/pubmed/21847050 | publisher = | date = | accessdate = }}</ref> | |||
==References== | ==References== | ||
Revision as of 14:37, 22 September 2015
|
Thymoma Microchapters |
|
Diagnosis |
|---|
|
Case Studies |
|
Thymoma natural history On the Web |
|
American Roentgen Ray Society Images of Thymoma natural history |
|
Risk calculators and risk factors for Thymoma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2] Ahmad Al Maradni, M.D. [3]
Overview
If left untreated thymoma may progress to invade the mediastinum and the surrounding structure. Depending on the stage of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good. Common complications of the thymoma include the pressure effect of the mass itself, autoimmune diseases, and rarely, malignancy.
Natural History, Complications and Prognosis
Natural history
The natural history of thymoma certainly illustrates the tendency for local mediastinal recurrence and plural ‘‘droplet’’ recurrence presumably caused by mediastinal plural invasion after resection. Local recurrences have been noted in the surgical incision used to completely remove a thymoma.[1]
Complications
the complication associated with thymoma may inculde:
- Pressure effect associated with thymoma (sometimes presented as superior vena cava syndrome)
- Autoimmune diseases associated with thymoma (e.g. myasthenia gravis, pure red cell aplasia)
- Thymomic malignancy of unknown etiology may arise
Complications of Radiotherapy
The most common complications of radiotherapy are:
The new technique of radiotherapy will hopefully has less toxicity.[1]
Complications of Surgery
The most common complications of thymectomy are:
- The complications of the procedure such as bleeding, infection, damage to other organs, nerve injuries(biateral phrenic nerve injury) and respiratory failure.
- Recurrence was described 10-20 years after removal of the primary lesion, so long term follow up is very important.
- Live attenuated vaccines such as yellow fever vaccine may have adverse side effect after thymectomy due to inadequate T-cell response.
Complications of Thymic Biopsy
The complications of the biopsy are:
Prognosis
The prognosis of thymoma depends on the following:
- The location of the tumor
- The stage of the tumor
- The Prognosis is much worse for stage III or IV thymomas as compared with stage I and II tumors. Invasive thymomas uncommonly can also metastasize, generally to pleura, bones, liver or brain in approximately 7% of cases.[2]
- Patients with stage III and IV tumors may nonetheless survive for several years with appropriate oncological management.
- Whether the tumor can be removed completely by surgery
- The patient's general health
- Whether the cancer has just been diagnosed or has recurred.
- The prognostic factors for recurrence and survival are the stage at diagnosis and whether a complete resection has been achieved.
- The histologic types include lymphocyte predominant, epithelial predominant, and mixed. The mixed histologic type was associated with the worst prognosis.
- the presence of myasthenia gravis at diagnosis is of less prognostic significance today.[1]
References
- ↑ 1.0 1.1 1.2 "Results of surgical treatment for t... [J Thorac Cardiovasc Surg. 1984] - PubMed - NCBI".
- ↑ Thomas CR, Wright CD, Loehrer PJ (1999). "Thymoma: state of the art". Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 17 (7): 2280–9. PMID 10561285. Text "accessdate" ignored (help); Unknown parameter
|month=ignored (help)