Non-Hodgkin lymphoma classification: Difference between revisions
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===A. Updated REAL/WHO classification=== | ===A. Updated REAL/WHO classification=== | ||
* Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups:<ref name=”cancergov”>National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq</ref> | * Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups:<ref name=”cancergov”>National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq</ref> | ||
* B-cell neoplasms | :* B-cell neoplasms | ||
* T-cell and putative NK-cell neoplasms | :* T-cell and putative NK-cell neoplasms | ||
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center | {| style="border: 0px; font-size: 90%; margin: 3px;" align=center | ||
|+ '''Updated REAL/WHO classification of Non-Hodgkin lymphoma''' | |||
! style="background: #4479BA; color:#FFF; text-align: center; font-weight: bold;" | B-cell neoplasms | ! style="background: #4479BA; color:#FFF; text-align: center; font-weight: bold;" | B-cell neoplasms | ||
! style="background: #4479BA; color:#FFF; text-align: center; font-weight: bold;" | T-cell and putative NK-cell neoplasms | ! style="background: #4479BA; color:#FFF; text-align: center; font-weight: bold;" | T-cell and putative NK-cell neoplasms | ||
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| style="padding: 5px 5px; background: #F5F5F5;" | Anaplastic large cell lymphoma, primary cutaneous type | | style="padding: 5px 5px; background: #F5F5F5;" | Anaplastic large cell lymphoma, primary cutaneous type | ||
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| | | style="padding: 5px 5px; background: #F5F5F5;" | | ||
| style="padding: 5px 5px; background: #F5F5F5;" | [[Aggressive NK-cell leukemia]] | | style="padding: 5px 5px; background: #F5F5F5;" | [[Aggressive NK-cell leukemia]] | ||
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Revision as of 15:46, 22 September 2015
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Non-Hodgkin lymphoma Microchapters |
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Differentiating Non-Hodgkin's Lymphoma |
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Treatment |
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Case Studies |
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Non-Hodgkin lymphoma classification On the Web |
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American Roentgen Ray Society Images of Non-Hodgkin lymphoma classification |
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Risk calculators and risk factors for Non-Hodgkin lymphoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups: B-cell neoplasms and T-cell and putative NK-cell neoplasms. Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:low-grade or indolent lymphoma and high-grade or aggressive lymphoma.
Classification of Non-Hodgkin lymphoma
A. Updated REAL/WHO classification
- Non-Hodgkin lymphoma may be classified according to updated REAL/WHO classification into 2 groups:[1]
- B-cell neoplasms
- T-cell and putative NK-cell neoplasms
| B-cell neoplasms | T-cell and putative NK-cell neoplasms |
|---|---|
| Precursor B-cell neoplasm | Precursor T-cell neoplasm |
| Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) | Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL) |
| Peripheral B-cell neoplasms | Peripheral T-cell and NK-cell neoplasms |
| B-cell CLL / small lymphocytic lymphoma | T-cell CLL / prolymphocytic leukemia |
| B-cell pro lymphocytic leukemia | T-cell granular lymphocytic leukemia |
| Lymphoplasmacytic lymphoma / immunocytoma | Mycosis fungoides / Sézary syndrome |
| Mantle cell lymphoma | Peripheral T-cell lymphoma, not otherwise characterized |
| Follicular lymphoma | Hepatosplenic gamma / delta T-cell lymphoma |
| Extra nodal marginal zone B-cell lymphoma of mucosa-associated lymphatic tissue (MALT) type | Subcutaneous panniculitis-like T-cell lymphoma |
| Nodal marginal zone B-cell lymphoma (± mono cytoid B-cells) | Angio immunoblastic T-cell lymphoma |
| Splenic marginal zone lymphoma (± villous lymphocytes) | Extranodal T-/NK-cell lymphoma, nasal type |
| Hairy cell leukemia | Enteropathy-type intestinal T-cell lymphoma |
| Plasmacytoma / plasma cell myeloma | Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+) |
| Diffuse large B-cell lymphoma | Anaplastic large cell lymphoma, primary systemic type |
| Burkitt lymphoma | Anaplastic large cell lymphoma, primary cutaneous type |
| Aggressive NK-cell leukemia |
B. Classification based on rate of growth
- Non-Hodgkin lymphoma may be classified based on rate of growth into 2 Groups:[2]
- Low-grade or Indolent lymphoma
- High-grade or Aggressive lymphoma
| Grade | Description |
|---|---|
| Low-grade or Indolent lymphoma | Tend to grow very slowly, tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen. Often treated only when symptoms appear. Can shrink or seem to disappear with treatment, but they tend to come back. Can change into more aggressive lymphomas. Have a fairly good prognosis. |
| High-grade or Aggressive lymphoma | Grow quickly and tend to spread to lymph nodes or other organs throughout the body. Cause symptoms and need treatment right away. Can frequently be successfully treated with intensive chemotherapy treatment. |
References
- ↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
- ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".