Thymoma pathophysiology: Difference between revisions
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| Neuromuscular Diseases ||[[Myasthenia gravis]], [[neuromyotonia]], rippling muscle disease, [[polymyositis]]/[[dermatomyositis]], [[encephalitis]] (limbic, cortical and brain stem), [[intestinal pseudoobstruction]] | | Neuromuscular Diseases ||[[Myasthenia gravis]], [[neuromyotonia]], rippling muscle disease, [[polymyositis]]/[[dermatomyositis]], [[encephalitis]] (limbic, cortical and brain stem), [[intestinal pseudoobstruction]] | ||
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| Haematologic Autoimmune Diseases ||[[Anemia]]: [[pure red cell aplasia]], [[pernicious anemia]], [[hemolytic anemia]] | | Haematologic Autoimmune Diseases ||[[Anemia]]: [[pure red cell aplasia]], [[pernicious anemia]], [[hemolytic anemia]], [[aplastic anemia]]. Other isolated cytopenis: [[eosinophils]], [[basophils]] and [[neutrophils]]. Immunodeficiencies: [[hypogammaglobulinaemia]] +/- T-cell deficiencies ([[Good syndrome]]) | ||
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| Dermatologic Diseases ||[[Pemphigus]] (foliaceus or paraneoplastic), [[lichen planus]], [[alopecia areata]] | | Dermatologic Diseases ||[[Pemphigus]] (foliaceus or paraneoplastic), [[lichen planus]], [[alopecia areata]] | ||
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| Endocrine Disorders ||[[Addison disease]], [[graves disease]] | | Endocrine Disorders ||[[Addison disease]], [[graves disease]], [[Cushing's disease]] | ||
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| Renal and Hepatic Diseases ||[[Glomerulonephritis]] | | Renal and Hepatic Diseases ||[[Glomerulonephritis]], [[autoimmune hepatitis]] | ||
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| Systemic Autoimmune Diseases ||[[SLE]], [[Sjögren's syndrome]], [[systemic sclerosis]] | | Systemic Autoimmune Diseases ||[[SLE]], [[Sjögren's syndrome]], [[systemic sclerosis]], [[graft-versus-host disease]] | ||
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==References== | ==References== | ||
Revision as of 17:05, 22 September 2015
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Thymoma Microchapters |
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Diagnosis |
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Case Studies |
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Thymoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Thymoma pathophysiology |
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Risk calculators and risk factors for Thymoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [2] Ahmad Al Maradni, M.D. [3]
Overview
On gross pathology, well circumscribed mass, that is locally invasive is a characteristic finding of thymoma. On gross pathology, well circumscribed mass, that is locally invasive is a characteristic finding of thymoma.
Pathophysiology
Microscopic Pathology
On microscopic histopathological analysis, round cells, with ample vacuolated cytoplasms, and fat droplets are characteristic findings of thymoma.
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Gross Pathology
On gross pathology, well circumscribed mass, that is locally invasive is a characteristic finding of thymoma.
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Genetic Features
Genetic alterations reported for the different WHO histological thymoma subtypes[1]
| WHO Type | Chromosomal Gains | Chromosomal Losses |
| Type A | none | -6p |
| Type AB | none | -5q21-22,-6q,-12p,-16q |
| Type B3 | +1q | -6,-13q |
Associated Disorders
30% of patients have their thymomas discovered, because they have an associated autoimmune disorder. These disorders include:[2]
| Type | Diseases |
| Neuromuscular Diseases | Myasthenia gravis, neuromyotonia, rippling muscle disease, polymyositis/dermatomyositis, encephalitis (limbic, cortical and brain stem), intestinal pseudoobstruction |
| Haematologic Autoimmune Diseases | Anemia: pure red cell aplasia, pernicious anemia, hemolytic anemia, aplastic anemia. Other isolated cytopenis: eosinophils, basophils and neutrophils. Immunodeficiencies: hypogammaglobulinaemia +/- T-cell deficiencies (Good syndrome) |
| Dermatologic Diseases | Pemphigus (foliaceus or paraneoplastic), lichen planus, alopecia areata |
| Endocrine Disorders | Addison disease, graves disease, Cushing's disease |
| Renal and Hepatic Diseases | Glomerulonephritis, autoimmune hepatitis |
| Systemic Autoimmune Diseases | SLE, Sjögren's syndrome, systemic sclerosis, graft-versus-host disease |
References
- ↑ "http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf" (PDF). Retrieved 26 February 2014. External link in
|title=(help) - ↑ "http://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/BB10.pdf" (PDF). External link in
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