Tumor lysis syndrome laboratory findings: Difference between revisions
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Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref> | ||
*Blood: | *Blood: | ||
:*Hyperuricemia ≥ 476 μmol/l | :*[[Hyperuricemia]] ≥ 476 μmol/l | ||
:*Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults) | :*[[Hyperphosphatemia]] ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults) | ||
:* | :*[[Hyperkalemia]] ≥ 6·0 mmol/l | ||
:* | :*[[Hypocalcemia]] ≤ 1·75 mmol/l | ||
*Urinalysis: | *Urinalysis: | ||
:*Low urine output | :*Low urine output | ||
Revision as of 18:03, 22 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum uric acid, potassium, phosphorus, and low calcium.[1]
Laboratory Findings
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:[1]
- Blood:
- Hyperuricemia ≥ 476 μmol/l
- Hyperphosphatemia ≥ 2·1 mmol/l (children), x ≥1·45 mmol/l (adults)
- Hyperkalemia ≥ 6·0 mmol/l
- Hypocalcemia ≤ 1·75 mmol/l
- Urinalysis:
- Low urine output
- Uric acid crystals or amorphous urates
- High uric acid-Creatinine ratio > 1.0
Cairo-Bishop Definition
- Laboratory tumor lysis syndrome: abnormalitiy in two or more of the following and occurs within 3 days before or 7 days after chemotherapy.
- uric acid > 8 mg/dL or 25% increase
- potassium > 6 meq/L or 25% increase
- phosphate > 4.5 mg/dL or 25% increase
- calcium < 7 mg/dL or 25% decrease
- Clinical tumor lysis syndrome: laboratory tumor lysis syndrome plus one or more of the following:
- increase serum creatinine (1.5 times upper limit of normal)
- cardiac arrhythmia or sudden death
- seizure
A grading scale (0-5) is used depending on the presence of lab TLS, serum creatinine, arrhythmias, or seizures.
References
- ↑ 1.0 1.1 Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.