Multiple myeloma other diagnostic studies: Difference between revisions
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==Cytogenetic Tests== | ==Cytogenetic Tests== | ||
'''[[Karyotyping]]''' | |||
:*Detects any [[chromosomal]] [[mutations]] occurring in multiple myeloma such as chromosome 13 deletion.<ref name="canada">Multiple myeloma. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015</ref><ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September 2015</ref> | :*Detects any [[chromosomal]] [[mutations]] occurring in multiple myeloma such as chromosome 13 deletion.<ref name="canada">Multiple myeloma. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015</ref><ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September 2015</ref> | ||
'''[[Fluorescent in situ hybridization]] (FISH)''' | |||
:*Detects any [[chromosomal]] [[mutations]] occurring in multiple myeloma such as chromosome 14 translocation.<<ref name="canada">Multiple myeloma. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015</ref><ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September 2015</ref> | :*Detects any [[chromosomal]] [[mutations]] occurring in multiple myeloma such as chromosome 14 translocation.<<ref name="canada">Multiple myeloma. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015</ref><ref name="wiki">Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September 2015</ref> | ||
Revision as of 18:52, 23 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Biopsy and genetic testing may be helpful in the diagnosis of multiple myeloma.[1] On bone marrow biopsy, multiple myeloma is characterized by an increase in percentage of abnormal plasma cells.[1] On genetic testing, multiple myeloma is characterized by chromosome 13 deletion and chromosome 14 translocation.[1][2]
Bone Marrow Biopsy
- Bone marrow biopsy is usually performed to estimate the percentage of bone marrow occupied by plasma cells.[1]
- Examination of abnormal plasma in the bone marrow is the only way to confirm a diagnosis.[1]
- The percentage of plasma cells is also used in the diagnostic criteria of multiple myeloma.Closing
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Cytogenetic Tests
- Detects any chromosomal mutations occurring in multiple myeloma such as chromosome 13 deletion.[1][2]
Fluorescent in situ hybridization (FISH)
- Detects any chromosomal mutations occurring in multiple myeloma such as chromosome 14 translocation.<[1][2]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Multiple myeloma. Canadian Cancer Society(2015) http://www.cancer.ca/en/cancer-information/cancer-type/multiple-myeloma/diagnosis/?region=mb#blood_chem Accessed on September, 20th 2015
- ↑ 2.0 2.1 2.2 Multiple myeloma. Wikipedia (2015)https://en.wikipedia.org/wiki/Multiple_myeloma#Pathophysiology Accessed on September 2015