Osteosarcoma staging

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Staging

• Historically, the Enneking staging system for skeletal malignancies was widely used.
• This system inferred the aggressiveness of the primary tumor by the descriptors intracompartmental or extracompartmental.
• The American Joint Committee on Cancer (AJCC) staging system for malignant bone tumors has updated this staging system, substituting compartmentalization with size.

TNM staging of osteosarcoma

Stage	Tumor grade	Tumor size
IA	Low	< 8 cm
IB	Low	> 8 cm
IIA	High	< 8 cm
IIB	High	> 8 cm
III	Any tumor grade, skip metastases
IV	Any tumor grade, any tumor size, distant metastases

Stage	Tumor Grade	Tumor Size
IA	Low	<8 cm
IB	Low	>8 cm
IIA	High	<8 cm
IIB	High	>8 cm
III	Any tumor grade, skip metastasesb
IV	Any tumor grade, any tumor size, distant metastases