Mediastinitis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
Mediastinitis is the inflammation or infection of the [[mediastinitum]].<ref name="pmid23372962">{{cite journal| author=Koksal D, Bayiz H, Mutluay N, Koyuncu A, Demirag F, Dagli G et al.| title=Fibrosing mediastinitis mimicking bronchogenic carcinoma. | journal=J Thorac Dis | year= 2013 | volume= 5 | issue= 1 | pages= E5-7 | pmid=23372962 | doi=10.3978/j.issn.2072-1439.2012.07.03 | pmc=PMC3548007 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23372962 }} </ref> | Mediastinitis is the inflammation or infection of the [[mediastinitum]].<ref name="pmid23372962">{{cite journal| author=Koksal D, Bayiz H, Mutluay N, Koyuncu A, Demirag F, Dagli G et al.| title=Fibrosing mediastinitis mimicking bronchogenic carcinoma. | journal=J Thorac Dis | year= 2013 | volume= 5 | issue= 1 | pages= E5-7 | pmid=23372962 | doi=10.3978/j.issn.2072-1439.2012.07.03 | pmc=PMC3548007 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23372962 }} </ref> Although the pathogenesis of the infection remains unknown, radiographic, serologic, or histopathologic evidence of prior ''Histoplasma capsulatum'' infection, [[histoplasmosis]], or [[chronic granulomatous disease]] is always observed. <ref> Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease. International Journal of Rheumatology (2012). http://www.hindawi.com/journals/ijr/2012/207056/ Accessed on September 25, 2015 </ref> | ||
==Pathophysiology== | ==Pathophysiology== | ||
===Gross Pathology=== | ===Gross Pathology=== | ||
On gross pathology, characteristic findings of mediastinitis include: | On gross pathology, characteristic findings of mediastinitis include: | ||
*White, | *White, fibrotic mass | ||
*Distinct gap with [[adipose|adipose fat]] | |||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
On microscopic histopathological analysis, characteristic findings of mediastinitis include: | On microscopic histopathological analysis, characteristic findings of mediastinitis include: | ||
==References== | ==References== | ||
Revision as of 20:58, 25 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Mediastinitis is the inflammation or infection of the mediastinitum.[1] Although the pathogenesis of the infection remains unknown, radiographic, serologic, or histopathologic evidence of prior Histoplasma capsulatum infection, histoplasmosis, or chronic granulomatous disease is always observed. [2]
Pathophysiology
Gross Pathology
On gross pathology, characteristic findings of mediastinitis include:
- White, fibrotic mass
- Distinct gap with adipose fat
Microscopic Pathology
On microscopic histopathological analysis, characteristic findings of mediastinitis include:
References
- ↑ Koksal D, Bayiz H, Mutluay N, Koyuncu A, Demirag F, Dagli G; et al. (2013). "Fibrosing mediastinitis mimicking bronchogenic carcinoma". J Thorac Dis. 5 (1): E5–7. doi:10.3978/j.issn.2072-1439.2012.07.03. PMC 3548007. PMID 23372962.
- ↑ Histopathologic Overlap between Fibrosing Mediastinitis and IgG4-Related Disease. International Journal of Rheumatology (2012). http://www.hindawi.com/journals/ijr/2012/207056/ Accessed on September 25, 2015