Meningioma natural history: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status. Common complications of meningioma include increased intracranial pressure, cranial nerve | If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status. Common complications of meningioma include increased intracranial pressure, cranial nerve palsies, and hydrocephalus. Prognosis is generally good, and the survival rate of patients with meningioma mainly depends on the grade and location of the tumor.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref><ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | ||
==Natural History== | ==Natural History== | ||
* Most patients with meningioma are asymptomatic. If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | |||
==Complications== | ==Complications== | ||
* Common complications of meningioma include:<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | |||
:* Increased intracranial pressure | |||
:* Cranial nerve palsies | |||
:* Hydrocephalus | |||
==Prognosis== | ==Prognosis== | ||
*Depending on the histological grade of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | * Depending on the histological grade of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | ||
*Grade 1 meningioma is associated with a median survival of approximately 10 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | * Grade 1 meningioma is associated with a median survival of approximately 10 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | ||
*Grade 3 meningioma is associated with a median survival of approximately 2.7 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | * Grade 3 meningioma is associated with a median survival of approximately 2.7 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | ||
*The table below lists common prognostic factors for meningioma:<ref name="Cr">Meningioma: Stages and Grades Cancer.net(2015) http://www.cancer.net/cancer-types/meningioma/stages-and-grades Accessed on September, 25th 2015</ref> | * The table below lists common prognostic factors for meningioma:<ref name="Cr">Meningioma: Stages and Grades Cancer.net(2015) http://www.cancer.net/cancer-types/meningioma/stages-and-grades Accessed on September, 25th 2015</ref> | ||
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Meningioma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Meningioma natural history On the Web |
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American Roentgen Ray Society Images of Meningioma natural history |
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Risk calculators and risk factors for Meningioma natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status. Common complications of meningioma include increased intracranial pressure, cranial nerve palsies, and hydrocephalus. Prognosis is generally good, and the survival rate of patients with meningioma mainly depends on the grade and location of the tumor.[1][2]
Natural History
- Most patients with meningioma are asymptomatic. If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status.[1]
Complications
- Common complications of meningioma include:[1]
- Increased intracranial pressure
- Cranial nerve palsies
- Hydrocephalus
Prognosis
- Depending on the histological grade of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.[1]
- Grade 1 meningioma is associated with a median survival of approximately 10 years.[2]
- Grade 3 meningioma is associated with a median survival of approximately 2.7 years.[2]
- The table below lists common prognostic factors for meningioma:[3]
| Prognostic Factor | Description |
| Age | Older patients are associated with a worse prognosis.[3] |
| Anatomical location | Meningioma located at the base of the skull is associated with poor prognosis due to difficult surgical resection.[3] |
| Labeling index using MIB-1 test | A greater MIB-1 index is associated with a worse prognosis.[3] |
| Histological grade | A grade 3 anaplastic meningioma is associated with the worst prognosis.[3] |
| Functional neurological status | Low score on the Karnofsky Performance Scale is associated with a worse prognosis.[3] |
| Sex hormone receptor | Meningiomas that lack progesterone receptor are associated with worse prognosis due to higher recurrence rate post surgery[2] |
References
- ↑ 1.0 1.1 1.2 1.3 Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015
- ↑ 2.0 2.1 2.2 2.3 Fathi AR, Roelcke U (2013). "Meningioma". Curr Neurol Neurosci Rep. 13 (4): 337. doi:10.1007/s11910-013-0337-4. PMID 23463172.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Meningioma: Stages and Grades Cancer.net(2015) http://www.cancer.net/cancer-types/meningioma/stages-and-grades Accessed on September, 25th 2015