Meningioma natural history: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status. Common complications of meningioma include increased intracranial pressure, cranial nerve palsies, and hydrocephalus. Prognosis is generally good, and the survival rate of patients with meningioma mainly depends on the grade and location of the tumor.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref><ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | If left untreated, patients with meningioma may progress to develop morning [[headache]], focal [[neurological]] deficit, and [[altered mental status]]. Common complications of meningioma include [[increased intracranial pressure]], [[cranial nerve palsies]], and [[hydrocephalus]]. Prognosis is generally good, and the survival rate of patients with meningioma mainly depends on the grade and location of the [[tumor]].<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref><ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | ||
==Natural History== | ==Natural History== | ||
* Most patients with meningioma are asymptomatic. If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | * Most patients with meningioma are [[asymptomatic]]. If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | ||
==Complications== | ==Complications== | ||
* Common complications of meningioma include:<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | * Common complications of meningioma include:<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | ||
:* Increased intracranial pressure | :* [[Increased intracranial pressure]] | ||
:* Cranial nerve palsies | :* [[Cranial nerve palsies]] | ||
:* Hydrocephalus | :* [[Hydrocephalus]] | ||
==Prognosis== | ==Prognosis== | ||
* Depending on the histological grade of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | * Depending on the [[histological]] grade of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.<ref name="Wiki">Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015</ref> | ||
* Grade 1 meningioma is associated with a median survival of approximately 10 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | * Grade 1 meningioma is associated with a median survival of approximately 10 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | ||
* Grade 3 meningioma is associated with a median survival of approximately 2.7 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | * Grade 3 meningioma is associated with a median survival of approximately 2.7 years.<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Anatomical location'''|| style="padding: 5px 5px; background: #F5F5F5;" |Meningioma located at the base of the skull is associated with poor prognosis due to difficult [[surgical resection]].<ref name="Cr">Meningioma: Stages and Grades Cancer.net(2015) http://www.cancer.net/cancer-types/meningioma/stages-and-grades Accessed on September, 25th 2015</ref> | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Anatomical location'''|| style="padding: 5px 5px; background: #F5F5F5;" |Meningioma located at the base of the [[skull]] is associated with poor prognosis due to difficult [[surgical resection]].<ref name="Cr">Meningioma: Stages and Grades Cancer.net(2015) http://www.cancer.net/cancer-types/meningioma/stages-and-grades Accessed on September, 25th 2015</ref> | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Sex hormone receptor'''|| style="padding: 5px 5px; background: #F5F5F5;" |Meningiomas that lack progesterone receptor are associated with worse prognosis due to higher recurrence rate post surgery<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" | '''Sex hormone receptor'''|| style="padding: 5px 5px; background: #F5F5F5;" |Meningiomas that lack [[progesterone]] [[receptor]] are associated with worse prognosis due to higher recurrence rate post surgery<ref name="pmid23463172">{{cite journal| author=Fathi AR, Roelcke U| title=Meningioma. | journal=Curr Neurol Neurosci Rep | year= 2013 | volume= 13 | issue= 4 | pages= 337 | pmid=23463172 | doi=10.1007/s11910-013-0337-4 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23463172 }} </ref> | ||
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Revision as of 20:44, 27 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status. Common complications of meningioma include increased intracranial pressure, cranial nerve palsies, and hydrocephalus. Prognosis is generally good, and the survival rate of patients with meningioma mainly depends on the grade and location of the tumor.[1][2]
Natural History
- Most patients with meningioma are asymptomatic. If left untreated, patients with meningioma may progress to develop morning headache, focal neurological deficit, and altered mental status.[1]
Complications
- Common complications of meningioma include:[1]
Prognosis
- Depending on the histological grade of the meningioma at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as good.[1]
- Grade 1 meningioma is associated with a median survival of approximately 10 years.[2]
- Grade 3 meningioma is associated with a median survival of approximately 2.7 years.[2]
- The table below lists common prognostic factors for meningioma:[3]
| Prognostic Factor | Description |
| Age | Older patients are associated with a worse prognosis.[3] |
| Anatomical location | Meningioma located at the base of the skull is associated with poor prognosis due to difficult surgical resection.[3] |
| Labeling index using MIB-1 test | A greater MIB-1 index is associated with a worse prognosis.[3] |
| Histological grade | A grade 3 anaplastic meningioma is associated with the worst prognosis.[3] |
| Functional neurological status | Low score on the Karnofsky Performance Scale is associated with a worse prognosis.[3] |
| Sex hormone receptor | Meningiomas that lack progesterone receptor are associated with worse prognosis due to higher recurrence rate post surgery[2] |
References
- ↑ 1.0 1.1 1.2 1.3 Meningioma. Wikipedia(2015) https://en.wikipedia.org/wiki/Meningioma#cite_ref-17 Accessed on September, 25th 2015
- ↑ 2.0 2.1 2.2 2.3 Fathi AR, Roelcke U (2013). "Meningioma". Curr Neurol Neurosci Rep. 13 (4): 337. doi:10.1007/s11910-013-0337-4. PMID 23463172.
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 Meningioma: Stages and Grades Cancer.net(2015) http://www.cancer.net/cancer-types/meningioma/stages-and-grades Accessed on September, 25th 2015