Carcinoma of the penis overview: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
Prognosis is generally good, and the 5-year survival rate of patients with penile cancer is approximately 67%. The prognosis varies with the stage of [[tumor]]; Stages 0–II have the most favorable prognosis. | [[Prognosis]] is generally good, and the 5-year survival rate of patients with penile cancer is approximately 67%. The prognosis varies with the stage of [[tumor]]; Stages 0–II have the most favorable prognosis. | ||
==Staging== | |||
Penile cancer may be classified into several subtypes based on [[TNM system]] and [[UICC]] staging system. | |||
==History and Symptoms== | |||
The most common symptoms of penile cencer include non-healing [[lesion]], change in the colour of the [[penis]], redness or [[irritation]] of the penis, [[lump]] or thickening of the [[skin]] on the [[penis]], [[phimosis]], foul-smelling [[discharge]] or [[bleeding]] from the penis or from underneath the [[foreskin]], [[itching]] or burning under the [[foreskin]], [[swelling]] of the penis, [[lump]] in the [[groin]], and [[dysuria]]. | |||
==Physical Examination== | |||
Common physical examination findings of penile cancer include [[weight loss]], [[pallor]], [[inguinal]] [[lymphadenopathy]], non-healing [[ulcer]] on the [[penis]], [[mass]] on the [[penis]], [[phimosis]], [[skin]] [[induration]] on the penis, change in the colour of the [[penis]], [[erythema]] of the penis, foul-smelling [[discharge]] or [[bleeding]] from the penis or from underneath the [[foreskin]], and [[swelling]] of the penis. | |||
==Laboratory Tests== | |||
Some patients with penile cancer may have elevated concentration of serum [[calcium]], which is usually suggestive of [[bone metastases]]. | |||
==X Ray== | |||
There are no [[x-ray]] findings associated with penile cancer. [[X-ray]] may be performed to detect [[metastases]] of penile cancer to [[lungs]] and [[bones]]. | |||
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Revision as of 19:11, 28 September 2015
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Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753; Joel Gelman, M.D. [2], Director of the Center for Reconstructive Urology and Associate Clinical Professor in the Department of Urology at the University of California,Irvine
Overview
Classification
Carcinoma of the penis may be classified according to cell types into several subtypes: squamous cell carcinoma, adenocarcinoma, melanoma, basal cell carcinoma, lymphoma, and sarcoma.
Pathophysiology
On gross pathology, scaly patches or nodules, erythematous, and ulceration are characteristic findings of carcinoma of the penis. On microscopic histopathological analysis, keratinization and intercellular bridges are characteristic findings of carcinoma of the penis.
Epidemiology and Demographics
The incidence of carcinoma of the penisis approximately 1 per 100,000 men in the United States.
Risk Factors
Common risk factors in the development of penile cancer are human papillomavirus, phimosis, poor genital hygiene, not being circumcised, weakened immune system, smoking, and treatment for psoriasis.
Screening
There is insufficient evidence to recommend routine screening for penile cancer.
Causes
Penile cancer is caused by an infection with human papillomavirus.
Differential Diagnosis
Penile cancer must be differentiated from condyloma acuminata, penile intraepithelial neoplasia (PeIN), balanitis xerotica obliterans, buschke-Lowenstein tumour, bowenoid papulosis, and leukoplakia.
Prognosis
Prognosis is generally good, and the 5-year survival rate of patients with penile cancer is approximately 67%. The prognosis varies with the stage of tumor; Stages 0–II have the most favorable prognosis.
Staging
Penile cancer may be classified into several subtypes based on TNM system and UICC staging system.
History and Symptoms
The most common symptoms of penile cencer include non-healing lesion, change in the colour of the penis, redness or irritation of the penis, lump or thickening of the skin on the penis, phimosis, foul-smelling discharge or bleeding from the penis or from underneath the foreskin, itching or burning under the foreskin, swelling of the penis, lump in the groin, and dysuria.
Physical Examination
Common physical examination findings of penile cancer include weight loss, pallor, inguinal lymphadenopathy, non-healing ulcer on the penis, mass on the penis, phimosis, skin induration on the penis, change in the colour of the penis, erythema of the penis, foul-smelling discharge or bleeding from the penis or from underneath the foreskin, and swelling of the penis.
Laboratory Tests
Some patients with penile cancer may have elevated concentration of serum calcium, which is usually suggestive of bone metastases.
X Ray
There are no x-ray findings associated with penile cancer. X-ray may be performed to detect metastases of penile cancer to lungs and bones.
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