Burkitt's lymphoma medical therapy: Difference between revisions
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{{CMG}}; {{AE}} {{AS}} | {{CMG}}; {{AE}} {{AS}} | ||
==Overview== | ==Overview== | ||
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required. | The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive [[immunotherapy]] and [[stem cell transplantation]] may be required. | ||
==Medical Therapy== | ==Medical Therapy== | ||
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* Drug Regimen: (Hyper-CVAD) [[Cyclophosphamide]], {{and}} [[Vincristine]], {{and}} [[Doxorubicin]], {{and}} [[Dexamethasone]], {{and}} [[Methotrexate]], {{and}} [[Cytarabine]] | * Drug Regimen: (Hyper-CVAD) [[Cyclophosphamide]], {{and}} [[Vincristine]], {{and}} [[Doxorubicin]], {{and}} [[Dexamethasone]], {{and}} [[Methotrexate]], {{and}} [[Cytarabine]] | ||
===Biological therapy=== | ===Biological therapy=== | ||
* Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma | * [[Monoclonal antibodies]] are a type of biological therapy that is effective in treating Burkitt's lymphoma | ||
* [[Rituximab]] may be added to each of the above chemotherapy regimens | * [[Rituximab]] may be added to each of the above chemotherapy regimens | ||
===CNS prophylaxis=== | ===CNS prophylaxis=== | ||
* There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS) | * There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS) | ||
* CNS prophylaxis may involve giving intrathecal chemotherapy high doses of systemic therapy, or both methods may be used | * CNS prophylaxis may involve giving [[intrathecal]] chemotherapy high doses of systemic therapy, or both methods may be used | ||
* [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis | * [[Methotrexate]] and [[Cytarabine]] are the drugs used most often for CNS prophylaxis | ||
===Stem cell transplant=== | ===Stem cell transplant=== | ||
* A | * A stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment | ||
==References== | ==References== | ||
Revision as of 20:22, 28 September 2015
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Burkitt's lymphoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Burkitt's lymphoma medical therapy On the Web |
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American Roentgen Ray Society Images of Burkitt's lymphoma medical therapy |
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Risk calculators and risk factors for Burkitt's lymphoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
The predominant therapy for Burkitt's lymphoma is chemotherapy. Adjunctive immunotherapy and stem cell transplantation may be required.
Medical Therapy
Chemotherapy
- Drug Regimen: (CODOX-M) Cyclophosphamide, AND Vincristine, AND Doxorubicin, AND Methotrexate
- Drug Regimen: (IVAC) Ifosfamide PLUS Mesna, AND Etoposide, AND Cytarabine
- Drug Regimen: (Hyper-CVAD) Cyclophosphamide, AND Vincristine, AND Doxorubicin, AND Dexamethasone, AND Methotrexate, AND Cytarabine
Biological therapy
- Monoclonal antibodies are a type of biological therapy that is effective in treating Burkitt's lymphoma
- Rituximab may be added to each of the above chemotherapy regimens
CNS prophylaxis
- There is a high risk that Burkitt's lymphoma will spread to the central nervous system (CNS)
- CNS prophylaxis may involve giving intrathecal chemotherapy high doses of systemic therapy, or both methods may be used
- Methotrexate and Cytarabine are the drugs used most often for CNS prophylaxis
Stem cell transplant
- A stem cell transplant may be offered to some people with Burkitt's lymphoma if their lymphoma returns or relapses after treatment