Carcinoid syndrome causes: Difference between revisions
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**Carcinoids associated with [[multiple endocrine neoplasia type 1]] appear to be of [[foregut]] origin. | **Carcinoids associated with [[multiple endocrine neoplasia type 1]] appear to be of [[foregut]] origin. | ||
** Carcinoids in patients with [[neurofibromatosis type 1]] appear to arise primarily in the periampullary region. | ** Carcinoids in patients with [[neurofibromatosis type 1]] appear to arise primarily in the periampullary region. | ||
* | *Genetic mutations | ||
**Gains involving chromosomes 5, 14, 17 | **Gains involving chromosomes 5, 14, 17, and 19 | ||
**Losses involving chromosomes 11 (especially 11q) and 18 | |||
==References== | ==References== |
Revision as of 15:07, 29 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Majority of the cases of gastrointestinal carcinoid are sporadic, however gastrointestinal carcinoid is associated with mutations in MEN1 and NF1 genes.
Causes
Common causes of carcinoid syndrome include:
- Genetic disorders
- Multiple endocrine neoplasia type 1
- Neurofibromatosis type 1.[1]
- Carcinoids associated with multiple endocrine neoplasia type 1 appear to be of foregut origin.
- Carcinoids in patients with neurofibromatosis type 1 appear to arise primarily in the periampullary region.
- Genetic mutations
- Gains involving chromosomes 5, 14, 17, and 19
- Losses involving chromosomes 11 (especially 11q) and 18
References
- ↑ Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq