Carcinoid syndrome causes: Difference between revisions
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{{Carcinoid syndrome}} | {{Carcinoid syndrome}} | ||
{{CMG}}{{AE}}{{PSD}} | {{CMG}}{{AE}}{{PSD}} | ||
==Overview== | ==Overview== | ||
Common causes of carcinoid syndrome include genetic disorders ([multiple endocrine neoplasia type 1]] and [[neurofibromatosis type 1]]) and genetic mutations (gains involving chromosomes 5, 14, 17, and 19 and losses involving chromosomes 11 and 18.<ref>Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | |||
==Causes== | ==Causes== | ||
Common causes of carcinoid syndrome include:<ref>Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | Common causes of carcinoid syndrome include:<ref>Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | ||
*Genetic disorders | *Genetic disorders | ||
**[[Multiple endocrine neoplasia type 1]] | |||
**[[Neurofibromatosis type 1]] | |||
**Carcinoids associated with [[multiple endocrine neoplasia type 1]] appear to be of [[foregut]] origin. | |||
** Carcinoids in patients with [[neurofibromatosis type 1]] appear to arise primarily in the periampullary region. | |||
*Genetic mutations | *Genetic mutations | ||
**Gains involving chromosomes 5, 14, 17, and 19 | **Gains involving chromosomes 5, 14, 17, and 19 | ||
**Losses involving chromosomes 11 | **Losses involving chromosomes 11 and 18 | ||
==References== | ==References== | ||
Revision as of 15:11, 29 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Common causes of carcinoid syndrome include genetic disorders ([multiple endocrine neoplasia type 1]] and neurofibromatosis type 1) and genetic mutations (gains involving chromosomes 5, 14, 17, and 19 and losses involving chromosomes 11 and 18.[1]
Causes
Common causes of carcinoid syndrome include:[2]
- Genetic disorders
- Multiple endocrine neoplasia type 1
- Neurofibromatosis type 1
- Carcinoids associated with multiple endocrine neoplasia type 1 appear to be of foregut origin.
- Carcinoids in patients with neurofibromatosis type 1 appear to arise primarily in the periampullary region.
- Genetic mutations
- Gains involving chromosomes 5, 14, 17, and 19
- Losses involving chromosomes 11 and 18
References
- ↑ Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq
- ↑ Molecular genetics. National Cancer Institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq