Optic nerve glioma epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Optic nerve gliomas typically present in children, and often in the setting of NF1 (10-63%). In this setting, the tumors are often low grade and indolent. In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found. 5 % of all childhood brain tumors account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas. It is most common in children who have the genetic condition neurofibromatosis 1 (NF1). Most optic gliomas are slow-growing and noncancerous and | Optic nerve gliomas typically present in children, and often in the setting of NF1 (10-63%). In this setting, the tumors are often low grade and indolent. In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found.<ref>{{Cite web | title =NIH optic glioma epidemiology| url =https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm}}</ref>. 5 % of all childhood brain tumors account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas.<ref name="pmid8009427">{{cite journal| author=Dutton JJ| title=Gliomas of the anterior visual pathway. | journal=Surv Ophthalmol | year= 1994 | volume= 38 | issue= 5 | pages= 427-52 | pmid=8009427 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8009427 }} </ref>It is most common in children who have the genetic condition neurofibromatosis 1 (NF1). Most optic gliomas occur in children, are slow-growing and noncancerous and almost always occur before age 20. 90 percent of optic nerve gliomas are diagnosed before the age of 20. 75 percent of optic nerve gliomas are diagnosed before the age of 10, 50 percent before the age of 5 and 25 percent before the age of 18 months.<ref name="pmid3275755">{{cite journal| author=Alvord EC, Lofton S| title=Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment. | journal=J Neurosurg | year= 1988 | volume= 68 | issue= 1 | pages= 85-98 | pmid=3275755 | doi=10.3171/jns.1988.68.1.0085 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3275755 }} </ref>. The mean age of presentation of optic nerve gliomas is 8.8 years.<ref>{{Cite web | title =NIH optic glioma epidemiology| url =https://www.nlm.nih.gov/medlineplus/ency/article/001024.htm}}</ref> | ||
The incidence of NF-1 among patients of optic nerve glioma is 10-70% and the incidence of optic nerve glioma in patients with NF-1 varies from 8 to 31 %.<ref name="pmid24736941">{{cite journal| author=Nair AG, Pathak RS, Iyer VR, Gandhi RA| title=Optic nerve glioma: an update. | journal=Int Ophthalmol | year= 2014 | volume= 34 | issue= 4 | pages= 999-1005 | pmid=24736941 | doi=10.1007/s10792-014-9942-8 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24736941 }} </ref> | |||
===Prevalence=== | ===Prevalence=== | ||
Prevalence of optic nerve glioma is approximately 1 per 100,000 patients presenting with eye complaints. | Prevalence of optic nerve glioma is approximately 1 per 100,000 patients presenting with eye complaints. | ||
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===Race=== | ===Race=== | ||
There are no racial or ethnic groups that are at more risk than others of optic nerve gliomas. | There are no racial or ethnic groups that are at more risk than others of optic nerve gliomas. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
The prevalence of optic nerve glioma is estimated to be 1 per 100, 000 patients presenting with eye complaints. Optic nerve gliomas affects girls and boys equally. There is no racial predilection to the optic nerve glioma.[1]
Epidemiology and Demographics
Optic nerve gliomas typically present in children, and often in the setting of NF1 (10-63%). In this setting, the tumors are often low grade and indolent. In adults, optic nerve gliomas do occur but are very rare and usually aggressive tumors. In such cases no association with NF1 has been found.[2]. 5 % of all childhood brain tumors account for optic nerve gliomas. About 1% of all intracranial tumors are comprised of optic-nerve gliomas.[3]It is most common in children who have the genetic condition neurofibromatosis 1 (NF1). Most optic gliomas occur in children, are slow-growing and noncancerous and almost always occur before age 20. 90 percent of optic nerve gliomas are diagnosed before the age of 20. 75 percent of optic nerve gliomas are diagnosed before the age of 10, 50 percent before the age of 5 and 25 percent before the age of 18 months.[4]. The mean age of presentation of optic nerve gliomas is 8.8 years.[5] The incidence of NF-1 among patients of optic nerve glioma is 10-70% and the incidence of optic nerve glioma in patients with NF-1 varies from 8 to 31 %.[6]
Prevalence
Prevalence of optic nerve glioma is approximately 1 per 100,000 patients presenting with eye complaints.
Gender
Boys and girls are equally affected.
Age
75% of people with optic pathway gliomas are younger than 10 years of age. The mean age of presentation of optic nerve glioma is 8.8 years.
Race
There are no racial or ethnic groups that are at more risk than others of optic nerve gliomas.
References
- ↑ "Radiopedia optic glioma epidemiology".
- ↑ "NIH optic glioma epidemiology".
- ↑ Dutton JJ (1994). "Gliomas of the anterior visual pathway". Surv Ophthalmol. 38 (5): 427–52. PMID 8009427.
- ↑ Alvord EC, Lofton S (1988). "Gliomas of the optic nerve or chiasm. Outcome by patients' age, tumor site, and treatment". J Neurosurg. 68 (1): 85–98. doi:10.3171/jns.1988.68.1.0085. PMID 3275755.
- ↑ "NIH optic glioma epidemiology".
- ↑ Nair AG, Pathak RS, Iyer VR, Gandhi RA (2014). "Optic nerve glioma: an update". Int Ophthalmol. 34 (4): 999–1005. doi:10.1007/s10792-014-9942-8. PMID 24736941.