Angiomyolipoma other diagnostic studies: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Angiomyolipoma}} | {{Angiomyolipoma}} | ||
{{CMG}} {{AE}}{{Faizan}} | |||
==Overview== | |||
CT guided biopsy is diagnostic of angiomyolipoma. | |||
==Biopsy Findings== | |||
Biopsy findings of angiomyolipoma include: | |||
===Microscopic Features=== | |||
Microscopic features of angiomyolipoma are: | |||
*Smooth muscle | |||
*Adipose tissue - not always present<ref name=pmid15584043>{{Cite journal | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref> - '''key feature''' | |||
*Abundant [[blood vessel]]s | |||
[[Image:Renal angiomyolipoma (1).jpg|200px|1. Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. H & E stain.]] | |||
[[Image:Renal angiomyolipoma (2).jpg|200px|2. Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. The same case as demonstrated in "Image 1". H & E stain.]] | |||
[[Image:Renal angiomyolipoma (3).jpg|200px|3. Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. The same case as demonstrated in "Image 1". H & E stain.]] | |||
[[Image:Renal angiomyolipoma (4) HMB-45 immunostain.JPG|200px|4. Histopathologic image of renal angiomyolipoma. Nephrectomy specimen. The same case as demonstrated in "Image 1". HMB-45 immunostain.]] | |||
[[Image:Angiomyolipoma-7_(1).jpg|200px]] | |||
===Cytologic=== | |||
Cytologic features of angiomyolipoma include:<ref name=pmid15584043>{{Cite journal | last1 = Crapanzano | first1 = JP. | title = Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases. | journal = Diagn Cytopathol | volume = 32 | issue = 1 | pages = 53-7 | month = Jan | year = 2005 | doi = 10.1002/dc.20179 | PMID = 15584043 }}</ref> | |||
*[[Nuclei]] - round/ovoid | |||
*[[Chromatin]] - bland | |||
===Immunohistochemistry=== | |||
Immunohistochemistry markers of angiomyolipoma include: | |||
*Melanocytic markers positive<ref name=Ref_GUP324>{{Ref GUP|324}}</ref> | |||
**HMB-45 positive in all cases (15/15)<ref name=pmid23932749>{{Cite journal | last1 = Esheba | first1 = Gel S. | last2 = Esheba | first2 = Nel S. | title = Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study. | journal = J Egypt Natl Canc Inst | volume = 25 | issue = 3 | pages = 125-34 | month = Sep | year = 2013 | doi = 10.1016/j.jnci.2013.05.002 | PMID = 23932749 }} | |||
</ref> | |||
**Melan A positive in ~87% of cases (13/15) | |||
*Epithelial markers negative<ref name=Ref_GUP324>{{Ref GUP|324}}</ref> | |||
**EMA | |||
**AE1/AE3 | |||
*SMA positive | |||
*CD117 positive/negative | |||
*Ki-67:<ref name=pmid18839327>{{Cite journal | last1 = Ooi | first1 = SM. | last2 = Vivian | first2 = JB. | last3 = Cohen | first3 = RJ. | title = The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma. | journal = Int Urol Nephrol | volume = 41 | issue = 3 | pages = 559-65 | month = | year = 2009 | doi = 10.1007/s11255-008-9473-1 | PMID = 18839327 }}</ref> | |||
**Epithelioid variant of [[angiomyolipoma]] positive | |||
**Conventional angiomyolipoma negative | |||
==References== | ==References== | ||
Revision as of 18:51, 29 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Faizan Sheraz, M.D. [2]
Overview
CT guided biopsy is diagnostic of angiomyolipoma.
Biopsy Findings
Biopsy findings of angiomyolipoma include:
Microscopic Features
Microscopic features of angiomyolipoma are:
- Smooth muscle
- Adipose tissue - not always present[1] - key feature
- Abundant blood vessels
.jpg)
.jpg)
.jpg)
_HMB-45_immunostain.JPG)
.jpg)
Cytologic
Cytologic features of angiomyolipoma include:[1]
Immunohistochemistry
Immunohistochemistry markers of angiomyolipoma include:
- Melanocytic markers positive[2]
- HMB-45 positive in all cases (15/15)[3]
- Melan A positive in ~87% of cases (13/15)
- Epithelial markers negative[2]
- EMA
- AE1/AE3
- SMA positive
- CD117 positive/negative
- Ki-67:[4]
- Epithelioid variant of angiomyolipoma positive
- Conventional angiomyolipoma negative
References
- ↑ 1.0 1.1 Crapanzano, JP. (2005). "Fine-needle aspiration of renal angiomyolipoma: cytological findings and diagnostic pitfalls in a series of five cases". Diagn Cytopathol. 32 (1): 53–7. doi:10.1002/dc.20179. PMID 15584043. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Template:Ref GUP
- ↑ Esheba, Gel S.; Esheba, Nel S. (2013). "Angiomyolipoma of the kidney: clinicopathological and immunohistochemical study". J Egypt Natl Canc Inst. 25 (3): 125–34. doi:10.1016/j.jnci.2013.05.002. PMID 23932749. Unknown parameter
|month=ignored (help) - ↑ Ooi, SM.; Vivian, JB.; Cohen, RJ. (2009). "The use of the Ki-67 marker in the pathological diagnosis of the epithelioid variant of renal angiomyolipoma". Int Urol Nephrol. 41 (3): 559–65. doi:10.1007/s11255-008-9473-1. PMID 18839327.