Carcinoid syndrome laboratory tests: Difference between revisions
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*Testing for elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%. | *Testing for elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%. | ||
*Plasma levels of CgA are very sensitive markers of carcinoid syndrome, but nonspecific as they are also elevated in other types of neuroendocrinal tumors, such as [[pancreatic]] and [[lung carcinoma|small cell lung carcinomas]]. | *Plasma levels of CgA are very sensitive markers of carcinoid syndrome, but nonspecific as they are also elevated in other types of neuroendocrinal tumors, such as [[pancreatic]] and [[lung carcinoma|small cell lung carcinomas]]. | ||
* | *Other biochemical markers associated with carcinoid syndrome include:<ref name=diagnostics>Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | ||
**[[Substance P]] | |||
*[[Neurotensin]] | |||
*[[Bradykinin]] | |||
*[[Human chorionic gonadotropin]] | |||
*Neuropeptide L | |||
*[[Pancreatic polypeptide]] | |||
==References== | ==References== | ||
Revision as of 19:38, 29 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.[1]
Laboratory Findings
- Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.[1]
- Testing for elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%.
- Plasma levels of CgA are very sensitive markers of carcinoid syndrome, but nonspecific as they are also elevated in other types of neuroendocrinal tumors, such as pancreatic and small cell lung carcinomas.
- Other biochemical markers associated with carcinoid syndrome include:[1]
- Neurotensin
- Bradykinin
- Human chorionic gonadotropin
- Neuropeptide L
- Pancreatic polypeptide
References
- ↑ 1.0 1.1 1.2 Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq