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==Overview==
==Overview==
Medulloblastoma may be classified into several subtypes based on WHO histological classification system (classic vs variant medulloblastoma) and the molecular subtypes classification system (WNT subgroup vs SHH subgroup vs Group 3 medulloblastoma vs Group 4 medulloblastoma).<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref><ref name="patho">Medulloblastoma. Librepathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015</ref><ref name="radio">Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015</ref>
Medulloblastoma may be classified into several subtypes based on WHO histological classification criteria (classic vs variant medulloblastoma) and the molecular subtypes classification criteria (WNT subgroup vs SHH subgroup vs Group 3 medulloblastoma vs Group 4 medulloblastoma).<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref><ref name="patho">Medulloblastoma. Librepathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015</ref><ref name="radio">Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015</ref>


==Classification==
==Classification==


===WHO histological classification system===
===WHO histological classification criteria===
* Medulloblastoma may be classified into two subtypes based on WHO histological classification system which include classic medulloblastoma and variant medulloblastoma.
* Medulloblastoma may be classified into two subtypes based on WHO histological classification criteria which include classic medulloblastoma and variant medulloblastoma.
* Other variants of medulloblastoma include desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic​ medulloblastoma and medulloblastoma with extensive nodularity.<ref name="patho">Medulloblastoma. Librepathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015</ref><ref name="radio">Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015</ref><ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref>
* Other variants of medulloblastoma include desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic​ medulloblastoma and medulloblastoma with extensive nodularity.<ref name="patho">Medulloblastoma. Librepathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015</ref><ref name="radio">Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015</ref><ref name="pmid17618441">{{cite journal| author=Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A et al.| title=The 2007 WHO classification of tumours of the central nervous system. | journal=Acta Neuropathol | year= 2007 | volume= 114 | issue= 2 | pages= 97-109 | pmid=17618441 | doi=10.1007/s00401-007-0243-4 | pmc=PMC1929165 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17618441  }} </ref>
<br>
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{{familytree/start |summary=WHO histological classification system}}
{{familytree/start |summary=WHO histological classification criteria}}
{{familytree | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 10em; padding:0em;">'''WHO histological classification system'''</div>}}
{{familytree | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 10em; padding:0em;">'''WHO histological classification criteria'''</div>}}
{{familytree | | |,|-|-|-|^|-|-|-|.| | | | | | }}
{{familytree | | |,|-|-|-|^|-|-|-|.| | | | | | }}
{{familytree | | A01 | | | | | | A03 | | | | |A01=<div style="width: 10em; padding:0em;">'''Classic medulloblastoma'''</div>|A03=<div style="width: 10em; padding:0em;">|A03=<div style="width: 10em; padding:0em;">'''Variant medulloblastoma'''</div>}}
{{familytree | | A01 | | | | | | A03 | | | | |A01=<div style="width: 10em; padding:0em;">'''Classic medulloblastoma'''</div>|A03=<div style="width: 10em; padding:0em;">|A03=<div style="width: 10em; padding:0em;">'''Variant medulloblastoma'''</div>}}
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<br>
<br>


===Molecular classification system===
===Molecular classification criteria===
* Medulloblastoma may be classified into at least four major subtypes based on molecular classification system which include WNT subgroup, SHH subgroup, Group C  and Group D medulloblastoma.<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref>
* Medulloblastoma may be classified into at least four major subtypes based on molecular classification criteria which include WNT subgroup, SHH subgroup, Group C  and Group D medulloblastoma.<ref name="pmid22832581">{{cite journal| author=Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T et al.| title=Subgroup-specific structural variation across 1,000 medulloblastoma genomes. | journal=Nature | year= 2012 | volume= 488 | issue= 7409 | pages= 49-56 | pmid=22832581 | doi=10.1038/nature11327 | pmc=PMC3683624 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22832581  }} </ref><ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref>
<br>
<br>
{{familytree/start |summary=Genomic classification system}}
{{familytree/start |summary=Genomic classification criteria}}
{{familytree | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 10em; padding:0em;">'''Genomic classification system'''</div>}}
{{familytree | | | | | | Y01 | | | | | | | | | Y01=<div style="width: 10em; padding:0em;">'''Genomic classification criteria'''</div>}}
{{familytree | | |,|-|-|-|+|-|-|-|v|-|-|-|.| | }}
{{familytree | | |,|-|-|-|+|-|-|-|v|-|-|-|.| | }}
{{familytree | | A01 | | A02 | | A03 | | A04  | | | | | A01=<div style="width: 10em; padding:0em;">'''WNT subgroup'''</div>|A02=<div style="width: 10em; padding:0em;">'''Sonic hedgehog (SHH) subgroup'''</div>|A03=<div style="width: 10em; padding:0em;">'''Group 3 medulloblastoma'''</div>|A04=<div style="width: 10em; padding:0em;">'''Group 4 medulloblastoma'''</div>}}
{{familytree | | A01 | | A02 | | A03 | | A04  | | | | | A01=<div style="width: 10em; padding:0em;">'''WNT subgroup'''</div>|A02=<div style="width: 10em; padding:0em;">'''Sonic hedgehog (SHH) subgroup'''</div>|A03=<div style="width: 10em; padding:0em;">'''Group 3 medulloblastoma'''</div>|A04=<div style="width: 10em; padding:0em;">'''Group 4 medulloblastoma'''</div>}}

Revision as of 01:42, 30 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Medulloblastoma may be classified into several subtypes based on WHO histological classification criteria (classic vs variant medulloblastoma) and the molecular subtypes classification criteria (WNT subgroup vs SHH subgroup vs Group 3 medulloblastoma vs Group 4 medulloblastoma).[1][2][3][4][5]

Classification

WHO histological classification criteria

  • Medulloblastoma may be classified into two subtypes based on WHO histological classification criteria which include classic medulloblastoma and variant medulloblastoma.
  • Other variants of medulloblastoma include desmoplastic medulloblastoma, large cell medulloblastoma, anaplastic​ medulloblastoma and medulloblastoma with extensive nodularity.[4][5][2]


 
 
 
 
 
WHO histological classification criteria
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Classic medulloblastoma
 
 
 
 
 
Variant medulloblastoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Desmoplastic medulloblastoma
 
Large cell medulloblastoma
 
Anaplastic​ medulloblastoma
 
Medulloblastoma with extensive nodularity
 
 
 
 


Molecular classification criteria

  • Medulloblastoma may be classified into at least four major subtypes based on molecular classification criteria which include WNT subgroup, SHH subgroup, Group C and Group D medulloblastoma.[1][3]


 
 
 
 
 
Genomic classification criteria
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
WNT subgroup
 
Sonic hedgehog (SHH) subgroup
 
Group 3 medulloblastoma
 
Group 4 medulloblastoma
 
 
 
 

References

  1. ↑ 1.0 1.1 Northcott PA, Shih DJ, Peacock J, Garzia L, Morrissy AS, Zichner T; et al. (2012). "Subgroup-specific structural variation across 1,000 medulloblastoma genomes". Nature. 488 (7409): 49–56. doi:10.1038/nature11327. PMC 3683624. PMID 22832581.
  2. ↑ 2.0 2.1 Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A; et al. (2007). "The 2007 WHO classification of tumours of the central nervous system". Acta Neuropathol. 114 (2): 97–109. doi:10.1007/s00401-007-0243-4. PMC 1929165. PMID 17618441.
  3. ↑ 3.0 3.1 Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395
  4. ↑ 4.0 4.1 Medulloblastoma. Librepathology(2015) http://librepathology.org/wiki/index.php/Medulloblastoma Accessed on September, 28th 2015
  5. ↑ 5.0 5.1 Medulloblastoma. radiopaedia(2015) http://radiopaedia.org/articles/medulloblastoma Accessed on September, 28th 2015
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