Carcinoid syndrome laboratory tests: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
*Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.<ref name=diagnostics>Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | *Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary [[5-hydroxyindoleacetic acid]] (5-HIAA) and plasma levels of CgA levels.<ref name=diagnostics>Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | ||
*Testing for elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%. | *Testing for elevated urinary [[5-hydroxyindoleacetic acid]] (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%. | ||
*Plasma levels of CgA are very sensitive markers of carcinoid syndrome, but not specific as they are also elevated in other types of neuroendocrinal tumors such as [[pancreatic]] and [[lung carcinoma|small cell lung carcinomas]]. | *Plasma levels of CgA are very sensitive markers of carcinoid syndrome, but not specific as they are also elevated in other types of neuroendocrinal tumors such as [[pancreatic]] and [[lung carcinoma|small cell lung carcinomas]]. | ||
*Other biochemical markers associated with carcinoid syndrome include:<ref name=diagnostics>Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | *Other biochemical markers associated with carcinoid syndrome include:<ref name=diagnostics>Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq</ref> | ||
Revision as of 14:40, 30 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.[1]
Laboratory Findings
- Laboratory findings consistent with the diagnosis of carcinoid syndrome include an elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) and plasma levels of CgA levels.[1]
- Testing for elevated urinary 5-hydroxyindoleacetic acid (5-HIAA) has a specificity of approximately 88%, although the sensitivity is reported to be as low as 35%.
- Plasma levels of CgA are very sensitive markers of carcinoid syndrome, but not specific as they are also elevated in other types of neuroendocrinal tumors such as pancreatic and small cell lung carcinomas.
- Other biochemical markers associated with carcinoid syndrome include:[1]
References
- ↑ 1.0 1.1 1.2 Diagnostics: Biochemical Markers, Imaging, and Approach. National cancer institute. http://www.cancer.gov/types/gi-carcinoid-tumors/hp/gi-carcinoid-treatment-pdq