Tumor lysis syndrome medical therapy: Difference between revisions
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Tumor lysis syndrome is a medical emergency and requires prompt treatment. | Tumor lysis syndrome is a medical emergency and requires prompt treatment. | ||
<ref name="pmid11694945">{{cite journal| author=Jeha S| title=Tumor lysis syndrome. | journal=Semin Hematol | year= 2001 | volume= 38 | issue= 4 Suppl 10 | pages= 4-8 | pmid=11694945 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11694945 }} </ref> | <ref name="pmid11694945">{{cite journal| author=Jeha S| title=Tumor lysis syndrome. | journal=Semin Hematol | year= 2001 | volume= 38 | issue= 4 Suppl 10 | pages= 4-8 | pmid=11694945 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11694945 }} </ref> | ||
==Medical Therapy== | ==Medical Therapy== | ||
The treatment of tumor lysis syndrome is a multidisciplinary effort between nephrologist, hematologist, and intensivist.<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972}}</ref><ref name="JonesWill2015">{{cite journal|last1=Jones|first1=Gail L|last2=Will|first2=Andrew|last3=Jackson|first3=Graham H|last4=Webb|first4=Nicholas J A|last5=Rule|first5=Simon|title=Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology|journal=British Journal of Haematology|volume=169|issue=5|year=2015|pages=661–671|issn=00071048|doi=10.1111/bjh.13403}}</ref> | The treatment of tumor lysis syndrome is a multidisciplinary effort between nephrologist, hematologist, and intensivist.<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972}}</ref><ref name="JonesWill2015">{{cite journal|last1=Jones|first1=Gail L|last2=Will|first2=Andrew|last3=Jackson|first3=Graham H|last4=Webb|first4=Nicholas J A|last5=Rule|first5=Simon|title=Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology|journal=British Journal of Haematology|volume=169|issue=5|year=2015|pages=661–671|issn=00071048|doi=10.1111/bjh.13403}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Tumor lysis syndrome is a medical emergency and requires prompt treatment. [1]
Medical Therapy
The treatment of tumor lysis syndrome is a multidisciplinary effort between nephrologist, hematologist, and intensivist.[2][3]
- Intravenous fluids:
- Aggressive hydration 3 l/m2/d
- Maintain urine output 4ml/kg/h for infants and 100ml/m2/h for adults
- Avoid adding potassium in hydration fluids
- Fluid loss should be measured, such as vomiting and diarrhea
- Elderly, infants, and patients with cardiac disease are at high risk of developing hypervolemia
- Mannitol 0·5 mg/kg
- Furosemide 0·5–1·0 mg/kg; 2–4 mg/kg in case of severe oliguria or anuria
- Note: Alkalization of urine is not recommended to increase the excretion of uric acid (the use of sodium bicarbonate is controversial).[4]
- Electrolytes disturbance:
- Hyperphosphataemia: treatment should be initiated if phosphorus levels are ≥2·1 mmol/l
- Avoid intra venous phosphate
- Aluminium hydroxide 15 ml q6h;poorly tolerated
- Hypocalcemia: treatment should be initiated if calcium levels are ≤1·75 mmol/l
- Asymptomatic: no treatment needed
- Symptomatic: calcium gluconate 50–100 mg/kg IV
- Cardiac monitoring is recommended if calcium level drops below ≤1.75mmol/l
- Asymptomatic (≥6·0 mmol/l): avoid potassium administration, ECG, and sodium polystyrene sulphonate
- Symptomatic (>7·0 mmol/l):
- Cardiac monitoring
- Calcium gluconate 100–200 mg/kg IV and/or
- Regular insulin 0·1 unit/kg IV + D25 2 ml/kg IV
- Dialysis
- Allopurinol 10 mg/kg/d divided q8 h, reduce the dose by 50% in renal failure
- Rasburicase 0·05–0·20 mg/kg IV over 30 min
- Note: the duration of treatment depends on the clinical response.
- Acute renal failure prior to chemotherapy:
- Acute renal failure after chemotherapy:
- The major cause of acute renal failure in this setting is hyperphosphatemia, and the main therapeutic means is hemodialysis. Forms of hemodialysis used include continuous arteriovenous hemodialysis (CAVHD), continuous venovenous hemofiltration (CVVH), or continuous venovenous hemodialysis (CVVHD).
References
- ↑ Jeha S (2001). "Tumor lysis syndrome". Semin Hematol. 38 (4 Suppl 10): 4–8. PMID 11694945.
- ↑ Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.
- ↑ Jones, Gail L; Will, Andrew; Jackson, Graham H; Webb, Nicholas J A; Rule, Simon (2015). "Guidelines for the management of tumour lysis syndrome in adults and children with haematological malignancies on behalf of the British Committee for Standards in Haematology". British Journal of Haematology. 169 (5): 661–671. doi:10.1111/bjh.13403. ISSN 0007-1048.
- ↑ Ten Harkel AD, Kist-Van Holthe JE, Van Weel M, Van der Vorst MM (1998). "Alkalinization and the tumor lysis syndrome". Med Pediatr Oncol. 31 (1): 27–8. PMID 9607427.