Pituitary adenoma pathophysiology: Difference between revisions
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*'''''Macroadenoma<ref name=radio>Pituitary adenoma. Dr Amir Rezaee and Dr Yuranga Weerakkody. Radiopaedia.org 2015.http://radiopaedia.org/articles/pituitary-adenoma</ref>''''' | *'''''Macroadenoma<ref name=radio>Pituitary adenoma. Dr Amir Rezaee and Dr Yuranga Weerakkody. Radiopaedia.org 2015.http://radiopaedia.org/articles/pituitary-adenoma</ref>''''' | ||
:*Pituitary macroadenomas are the most common [[suprasellar]] mass in adults. They are defined as adenomas greater than 10 mm in size and are most frequently diagnosed due to compression of the surrounding structures, such as [[optic chiasm]]. | :*Pituitary macroadenomas are the most common [[suprasellar]] mass in adults. | ||
:*They are defined as adenomas greater than 10 mm in size and are most frequently diagnosed due to compression of the surrounding structures, such as [[optic chiasm]]. | |||
:*Larger adenomas can lead to hormonal imbalance due to mass effect rather than secretion. | :*Larger adenomas can lead to hormonal imbalance due to mass effect rather than secretion. | ||
:*[[Hypopituitarism]] or moderately elevated [[prolactin]] are both seen, the later due to stalk effect; prolactin release (unlike other pituitary hormones) is tonically inhibited by prolactin inhibitory hormone (a.k.a. dopamine) and as such compression of the pituitary infundibulum can result in elevation of systemic prolactin levels due to interruption of normal inhibition. | :*[[Hypopituitarism]] or moderately elevated [[prolactin]] are both seen, the later due to stalk effect; prolactin release (unlike other pituitary hormones) is tonically inhibited by prolactin inhibitory hormone (a.k.a. dopamine) and as such compression of the pituitary infundibulum can result in elevation of systemic prolactin levels due to interruption of normal inhibition. | ||
*Macroadenomas are approximately twice as common as micoadenoma. | :*Macroadenomas are approximately twice as common as micoadenoma. | ||
:*Pituitary microadenomas are | *'''''Microadenoma<ref name=Radiopaedia> pituitary micro adenoma Dr Amir Rezaee and Dr Frank Gaillard. 2015 http://radiopaedia.org/articles/pituitary-microadenoma</ref>''''' | ||
:*Pituitary microadenomas are defined as adenomas less than 10 mm in size. | |||
:* | :*Most frequently diagnosed as the result of investigating hormonal imbalance. | ||
:* They are confined to the [[sella]] and has no scope to produce symptoms due to mass effect. | |||
==References== | ==References== | ||
Revision as of 15:45, 30 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Pathophysiology
- Macroadenoma[1]
- Pituitary macroadenomas are the most common suprasellar mass in adults.
- They are defined as adenomas greater than 10 mm in size and are most frequently diagnosed due to compression of the surrounding structures, such as optic chiasm.
- Larger adenomas can lead to hormonal imbalance due to mass effect rather than secretion.
- Hypopituitarism or moderately elevated prolactin are both seen, the later due to stalk effect; prolactin release (unlike other pituitary hormones) is tonically inhibited by prolactin inhibitory hormone (a.k.a. dopamine) and as such compression of the pituitary infundibulum can result in elevation of systemic prolactin levels due to interruption of normal inhibition.
- Macroadenomas are approximately twice as common as micoadenoma.
- Microadenoma[2]
- Pituitary microadenomas are defined as adenomas less than 10 mm in size.
- Most frequently diagnosed as the result of investigating hormonal imbalance.
- They are confined to the sella and has no scope to produce symptoms due to mass effect.
References
- ↑ Pituitary adenoma. Dr Amir Rezaee and Dr Yuranga Weerakkody. Radiopaedia.org 2015.http://radiopaedia.org/articles/pituitary-adenoma
- ↑ pituitary micro adenoma Dr Amir Rezaee and Dr Frank Gaillard. 2015 http://radiopaedia.org/articles/pituitary-microadenoma