Medulloblastoma epidemiology and demographics: Difference between revisions

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==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Prevalance===
===Prevalance===
===Incidence===
* The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828  }} </ref>


Medulloblastoma is the most common malignant brain tumor, comprising 14.5% of newly diagnosed cases.<ref name="seer">James G. Gurney, Malcolm A. Smith, Greta R. Bunin, [http://seer.cancer.gov/publications/childhood/cns.pdf CNS and Miscellaneous Intracranial and Intraspinal Neoplasms], SEER Pediatric Monograph, National Cancer Institute</ref>


In adults, medulloblastoma is rare, comprising less than 2% of CNS malignancies.<ref>[http://cbtrus.org/2005-2006/tables/2006.table12.pdf Selected Primary Brain and Central Nervous System Tumor Age-Specific Incidence Rates], Central Brain Tumor Registry of the United States, 1998-2002.</ref>


* Medulloblastoma and other PNET tumors are more prevalent in younger children than older children.
===Incidence===
:* 40% of medulloblastoma patients are diagnosed before the age of 5
* The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828  }} </ref>
:* 31% are between the ages of 5 and 9
 
:* 18.3% are between the ages of 10 and 14
 
2.7% are between the ages of 15 and 19. <ref>[http://cbtrus.org/2005-2006/tables/2006.table15.pdf Selected Childhood Primary Brain and Central Nervous System Tumor Age-Specific Incidence Rates], Central Brain Tumor Registry of the United States, 1998-2002.</ref>


===Age===
===Age===
* Medulloblastoma is the second most common brain tumor among the pediatric population, as it comprise 14.5% of newly diagnosed cases.<ref name="wiki">Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015</ref>
* Medulloblastoma is considered a rare tumor among adults , as it compromise fewer than 2% of all brain tumors.
* The molecular subtgroup of medulloblastoma influence the age of presentation such as:<ref name="pmid22189395">Leary SE, Olson JM (2012) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=22189395 The molecular classification of medulloblastoma: driving the next generation clinical trials.] ''Curr Opin Pediatr'' 24 (1):33-9. [http://dx.doi.org/10.1097/MOP.0b013e32834ec106 DOI:10.1097/MOP.0b013e32834ec106] PMID: [http://pubmed.gov/22189395 22189395]</ref>
:* WNT medulloblastoma  subgroup present among older children
:* SHH medulloblastoma subgroup present among infants and adults
:*  Group 3 medulloblastoma present among younger children
:*  Group 4 medulloblastoma present among younger younger children
===Gender===
===Gender===
* The overall age adjusted incidence rate of medulloblastoma among male patients is approximately 0.84 per 100,000 individuals in the United States.<ref name="pmid23925828">{{cite journal| author=McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M et al.| title=Trends in childhood brain tumor incidence, 1973-2009. | journal=J Neurooncol | year= 2013 | volume= 115 | issue= 2 | pages= 153-60 | pmid=23925828 | doi=10.1007/s11060-013-1212-5 | pmc=PMC4056769 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23925828  }} </ref>
* The overall age adjusted incidence rate of medulloblastoma among female patients is approximately 0.58 per 100,000 individuals in the United States.
* Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.
===Race===
===Race===


Revision as of 18:29, 30 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Epidemiology and Demographics

Prevalance

Incidence

  • The overall age adjusted incidence rate of medulloblastoma is approximately 0.71 per 100,000 individuals in the United States.[1]

Age

  • Medulloblastoma is the second most common brain tumor among the pediatric population, as it comprise 14.5% of newly diagnosed cases.[2]
  • Medulloblastoma is considered a rare tumor among adults , as it compromise fewer than 2% of all brain tumors.
  • The molecular subtgroup of medulloblastoma influence the age of presentation such as:[3]
  • WNT medulloblastoma subgroup present among older children
  • SHH medulloblastoma subgroup present among infants and adults
  • Group 3 medulloblastoma present among younger children
  • Group 4 medulloblastoma present among younger younger children

Gender

  • The overall age adjusted incidence rate of medulloblastoma among male patients is approximately 0.84 per 100,000 individuals in the United States.[1]
  • The overall age adjusted incidence rate of medulloblastoma among female patients is approximately 0.58 per 100,000 individuals in the United States.
  • Males are more commonly affected with medulloblastoma than females. The male to female ratio is approximately 1.44 to 1.

Race

References

  1. ↑ 1.0 1.1 McKean-Cowdin R, Razavi P, Barrington-Trimis J, Baldwin RT, Asgharzadeh S, Cockburn M; et al. (2013). "Trends in childhood brain tumor incidence, 1973-2009". J Neurooncol. 115 (2): 153–60. doi:10.1007/s11060-013-1212-5. PMC 4056769. PMID 23925828.
  2. ↑ Medulloblastoma. Wikipedia(2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September, 28th 2015
  3. ↑ Leary SE, Olson JM (2012) The molecular classification of medulloblastoma: driving the next generation clinical trials. Curr Opin Pediatr 24 (1):33-9. DOI:10.1097/MOP.0b013e32834ec106 PMID: 22189395


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