Osteosarcoma risk factors

Osteosarcoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Osteosarcoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Biopsy
X Ray
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Osteosarcoma risk factors On the Web
Most recent articles
cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Osteosarcoma risk factors All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Osteosarcoma risk factors
CDC on Osteosarcoma risk factors
Osteosarcoma risk factors in the news
Blogs on Osteosarcoma risk factors
Directions to Hospitals Treating Osteosarcoma
Risk calculators and risk factors for Osteosarcoma risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]

Overview

The common risk factors in the development of osteosarcoma are radiation to bones, alkylating antineoplastic agents, Paget disease, multiple hereditary osteochondromas, fibrous dysplasia, Bloom syndrome,Rothmund-Thomson syndrome, and Li-Fraumeni syndrome.

Risk Factors

• Age and height: Data suggest that the risk of osteosarcoma is highest during the teenage "growth spurt." Children with osteosarcoma are usually tall for their age.
• Radiation to bones: People who were treated with radiation for another cancer have a higher risk of later developing post-radiation (after radiation) osteosarcoma.
• Drugs: Past treatment with anticancer drugs called alkylating antineoplastic agents.
• Certain bone diseases:

• Paget disease of bone
• Multiple hereditary osteochondromas
• Fibrous dysplasia
• Enchondromtosis.

• Inherited cancer syndromes: Genetic diseases that Predispose to osteosarcoma are:

• Bloom syndrome
• Diamond-Blackfan anemia
• Familial adenomatous polyposis
• Li-Fraumeni syndrome
• Hereditary retinoblastoma
• Rothmund-Thomson syndrome
• Werner syndrome
• RAPADILINO syndrome