Pituitary adenoma pathophysiology: Difference between revisions
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{{CMG}} {{AE}} {{AAM}} | {{CMG}} {{AE}} {{AAM}} | ||
==Overview== | ==Overview== | ||
On gross pathology, a well circumscribed suprasellar mass is a characteristic finding of pituitary adenoma. | On gross pathology, a well circumscribed [[suprasellar]] mass is a characteristic finding of pituitary adenoma. | ||
On microscopic histopathological analysis, the lack of reticulin fiber network among the cells is a characteristic finding of pituitary adenoma. | On microscopic histopathological analysis, the lack of [[reticulin]] fiber network among the cells is a characteristic finding of pituitary adenoma. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 19:53, 30 September 2015
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Pituitary adenoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
On gross pathology, a well circumscribed suprasellar mass is a characteristic finding of pituitary adenoma. On microscopic histopathological analysis, the lack of reticulin fiber network among the cells is a characteristic finding of pituitary adenoma.
Pathophysiology
- Macroadenoma[1]
- Pituitary macroadenomas are the most common suprasellar mass in adults.
- They are defined as adenomas greater than 10 mm in size and are most frequently diagnosed due to compression of the surrounding structures, such as optic chiasm.
- Larger adenomas can lead to hormonal imbalance due to mass effect rather than secretion.
- Hypopituitarism or moderately elevated prolactin are both seen, the later due to stalk effect; prolactin release (unlike other pituitary hormones) is tonically inhibited by prolactin inhibitory hormone (a.k.a. dopamine) and as such compression of the pituitary infundibulum can result in elevation of systemic prolactin levels due to interruption of normal inhibition.
- Macroadenomas are approximately twice as common as micoadenoma.
- Microadenoma[2]
- Pituitary microadenomas are defined as adenomas less than 10 mm in size.
- Most frequently diagnosed as a result of investigating hormonal imbalance.
- They are confined to the sella and has no scope to produce mass effect related symptoms.
References
- ↑ Pituitary adenoma. Dr Amir Rezaee and Dr Yuranga Weerakkody. Radiopaedia.org 2015.http://radiopaedia.org/articles/pituitary-adenoma
- ↑ pituitary micro adenoma Dr Amir Rezaee and Dr Frank Gaillard. 2015 http://radiopaedia.org/articles/pituitary-microadenoma