Ewing's sarcoma pathophysiology: Difference between revisions
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*It consists of a [[homogeneous]] population of small round cells that have a high [[nuclear]] to [[cytoplasmic]] ratio. | *It consists of a [[homogeneous]] population of small round cells that have a high [[nuclear]] to [[cytoplasmic]] ratio. | ||
*The population of small round cells are arrayed in sheets. | *The population of small round cells are arrayed in sheets. | ||
*There is a presence of scant | *There is a presence of scant cytoplasm which are pale, vacuolated, and are characterized by their faded boundaries.<ref name="pmid17272319">{{cite journal |author=Iwamoto Y |title=Diagnosis and treatment of Ewing's sarcoma |journal=[[Japanese Journal of Clinical Oncology]] |volume=37 |issue=2 |pages=79–89 |year=2007 |month=February |pmid=17272319 |doi=10.1093/jjco/hyl142 |url=http://jjco.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17272319 |accessdate=2012-01-04}}</ref> | ||
*The [[nuclei]] have intense color which make them easily visible. | *The [[nuclei]] have intense color which make them easily visible. | ||
*Cytoplasmic [[glycogen]] is also usually present. | *Cytoplasmic [[glycogen]] is also usually present. | ||
Revision as of 14:40, 5 October 2015
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Ewing's sarcoma Microchapters |
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Treatment |
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Ewing's sarcoma pathophysiology On the Web |
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Risk calculators and risk factors for Ewing's sarcoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Michael Maddaleni, B.S.
Pathophysiology
Genetics
- Ewing sarcoma is the result of a translocation between chromosomes 11 and 22, which fuses the EWS gene of chromosome 22 to the FLI1 gene of chromosome 11.
- The EWSR1 gene is a member of the TET family [TLS/EWS/TAF15] of RNA-binding proteins. The FLI1 gene is a member of the ETS family of DNA-binding genes.
- Characteristically, the amino terminus of the EWSR1 gene is juxtaposed with the carboxy terminus of the ETS family gene.
- In most cases (90%), the carboxy terminus is provided by FLI1, a member of the family of transcription factor genes located on chromosome 11 band q24.
- Other family members that may combine with the EWSR1 gene are ERG, ETV1, ETV4 (also termed E1AF), and FEV.
- Rarely, TLS, another TET family member, can substitute for EWSR1.
Microscopic pathology
Ewing sarcoma is a small round blue cell tumor with regular sized primitive appearing cells:
- It consists of a homogeneous population of small round cells that have a high nuclear to cytoplasmic ratio.
- The population of small round cells are arrayed in sheets.
- There is a presence of scant cytoplasm which are pale, vacuolated, and are characterized by their faded boundaries.[1]
- The nuclei have intense color which make them easily visible.
- Cytoplasmic glycogen is also usually present.
References
- ↑ Iwamoto Y (2007). "Diagnosis and treatment of Ewing's sarcoma". Japanese Journal of Clinical Oncology. 37 (2): 79–89. doi:10.1093/jjco/hyl142. PMID 17272319. Retrieved 2012-01-04. Unknown parameter
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