Oligodendroglioma differential diagnosis: Difference between revisions
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==Differentiating Oligodendroglioma from other Diseases== | ==Differentiating Oligodendroglioma from other Diseases== | ||
Oligodendroglioma must be differentiated from: | Oligodendroglioma must be differentiated from: | ||
(Their name derives from the Greek roots 'oligo' meaning “ few” and 'dendro' meaning “trees”.) | |||
Classically they tend to have a vasculature of finely branching capillaries that may take on a “chicken wire” appearance . When invading grey matter structures such as cortex, the neoplastic oligodendrocytes tend to cluster around [[neurons]] exhibiting a phenomenon referred to as “perineuronal satellitosis”. Oligodendrogliomas may invade preferentially around vessels or under the [[pia mater|pial]] surface of the brain. | Classically they tend to have a vasculature of finely branching capillaries that may take on a “chicken wire” appearance . When invading grey matter structures such as cortex, the neoplastic oligodendrocytes tend to cluster around [[neurons]] exhibiting a phenomenon referred to as “perineuronal satellitosis”. Oligodendrogliomas may invade preferentially around vessels or under the [[pia mater|pial]] surface of the brain. | ||
Revision as of 19:38, 6 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Oligodendroglioma must be differentiated from:
Differentiating Oligodendroglioma from other Diseases
Oligodendroglioma must be differentiated from: (Their name derives from the Greek roots 'oligo' meaning “ few” and 'dendro' meaning “trees”.)
Classically they tend to have a vasculature of finely branching capillaries that may take on a “chicken wire” appearance . When invading grey matter structures such as cortex, the neoplastic oligodendrocytes tend to cluster around neurons exhibiting a phenomenon referred to as “perineuronal satellitosis”. Oligodendrogliomas may invade preferentially around vessels or under the pial surface of the brain.
Oligodendrogliomas must be differentiated from the more common astrocytoma. Non-classical variants and combined tumors of both oligodendroglioma and astrocytoma differentiation are seen, making this distinction controversial between different neuropathology groups. In the US, in general, neuropathologists trained on the West Coast are more liberal in the diagnosis of oligodendroliomas than either East Coast or Midwest trained neuropathologists who render the diagnosis of oligodendroglioma for only classic variants. Molecular diagnostics may make this differentiation obsolete in the future.
Other glial and glioneuronal tumors with which they are often confused due to their monotonous round cell appearance include pilocytic astrocytoma, central neurocytoma, the so-called dysembryoplastic neuroepithelial tumor, or occasionally ependymoma.