B-cell prolymphocytic leukemia overview: Difference between revisions
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==Diagnosis== | ==Diagnosis== | ||
===History and Symptoms=== | ===History and Symptoms=== | ||
Symptoms of B-cell prolymphocytic leukemia include generalised weakness and, [[anemia]], massive splenomegaly, [[weight loss]], loss of appetite, [[thrombocytopenia]] and | |||
peripheral lymphadenopathy. | |||
===Physical Examination=== | ===Physical Examination=== | ||
Common physical examination findings of [[B-cell prolymphocytic leukemia]] include [[tachycardia]], [[pallor]], [[splenomegaly]] and [[lymphadenopathy]]. | |||
===Laboratory Findings=== | ===Laboratory Findings=== | ||
Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include [[full blood count|complete blood count]], abnormal blood chemistry studies and abnormal blood peripheral smear. | |||
===Chest X Ray=== | ===Chest X Ray=== | ||
Revision as of 14:54, 7 October 2015
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B-cell prolymphocytic leukemia |
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Differentiating B-cell prolymphocytic leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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B-cell prolymphocytic leukemia overview On the Web |
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American Roentgen Ray Society Images of B-cell prolymphocytic leukemia overview |
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Directions to Hospitals Treating B-cell prolymphocytic leukemia |
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Risk calculators and risk factors for B-cell prolymphocytic leukemia overview |
For patient information click here
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]
Synonyms and keywords: B-PLL, Prolymphocytic leukemia, B-cell type
Overview
B-cell prolymphocytic leukemia is a form of leukemia or cancer of the white blood cells
Historical Perspective
Classification
Pathophysiology
B-cell prolymphocytic leukemia arises from mature B-cells, which are hematologic white cells that are normally involved in the in the humoral immunity component of the adaptive immune system by secreting antibodies.
Differentiating B-cell prolymphocytic leukemia from other Diseases
B-cell prolymphocytic leukemia must be differentiated from other diseases such as T-cell prolymphocytic leukemia, chronic lymphocytic leukemia and hairy cell leukemia.
Epidemiology and Demographics
The incidence of B-cell prolymphocytic leukemia is 1% of lymphocytic leukemias. B-cell prolymphocytic leukemia affects men and women equally.
Risk Factors
Screening
Natural History, Complications and Prognosis
The prognosis for B-cell prolymphocytic leukemia is generally poor.
Diagnosis
History and Symptoms
Symptoms of B-cell prolymphocytic leukemia include generalised weakness and, anemia, massive splenomegaly, weight loss, loss of appetite, thrombocytopenia and peripheral lymphadenopathy.
Physical Examination
Common physical examination findings of B-cell prolymphocytic leukemia include tachycardia, pallor, splenomegaly and lymphadenopathy.
Laboratory Findings
Laboratory findings consistent with the diagnosis of acute lymphoblastic leukemia include complete blood count, abnormal blood chemistry studies and abnormal blood peripheral smear.