Hyperventilation

Hyperventilation
ICD-10	R06.4
ICD-9	786.01

Tachypnea
ICD-10	R06.0
ICD-9	786.06

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

In medicine, hyperventilation (or overbreathing) is the state of breathing faster and/or deeper than necessary, thereby reducing the carbon dioxide concentration of the blood below normal.

This is in contrast to hyperpnea, where the increased breathing is required to meet demand, as during and following exercise or when the body lacks oxygen (hypoxia), for instance in high altitude or as a result of anaemia. Hyperpnea may also occur as a result of sepsis, and is usually a sign of the beginning of refractory sepsis.

Hyperventilation can, but does not necessarily cause symptoms such as numbness or tingling in the hands, feet and lips, lightheadedness, dizziness, headache, chest pain, slurred speech and sometimes fainting, particularly when accompanied by the Valsalva maneuver. Sometimes hyperventilation is induced for these same effects. Hyperventilation can sometimes be self induced for moments of needed focus and adrenaline.

The related symptom tachypnea (or "tachypnoea") (Greek: "rapid breathing") is characterized by rapid breathing and is not identical with hyperventilation - tachypnea may be necessary for a sufficient gas-exchange of the body, for example after exercise, in which case it is not hyperventilation.

Life-Threatening Causes

Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.

• Life threatening causes do not include chronic conditions.
• Make sure to include the following definition underneath the subheading of every life threatening causes section: Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
• The list of life threatening causes is arranged in alphabetical order.
• If the page's disease is itself life-threatening, do not add causes in the life-threatening causes section. Instead, write the following sentence under the subheading: Disease name is a life-threatening condition and must be treated as such irrespective of the causes. Life-threatening conditions may result in death or permanent disability within 24 hours if left untreated.

Causes by Organ System

Cardiovascular	Cheyne-stokes respirations, congestive cardiac failure,pulmonary embolism, stroke
Chemical/Poisoning	Ammonium chloride ,camphor ,glycol ether ,inhalation of irritants,methanol ,Salicylate poisoning,
Dental	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Aminophylline, aspirin, coffee abuse, pralidoxime, tiagabine
Ear Nose Throat	No underlying causes
Endocrine	Diabetic ketoacidosis, renal disease
Environmental	Acute stress disorder
Gastroenterologic	Abdominal surgery, acute liver failure, acute porphyria, end stage liver failure , hepatic cirrhosis, intestinal fistula, pyloric stenosis
Genetic	Acute porphyria, arginosuccinic aciduria, carbamoylphosphate synthetase 1 deficiency disease, carbonic anhydrase va deficiency, hereditary fructose-1,6-bisphosphatase deficiency, Pitt-hopkins syndrome
Hematologic	Acute porphyria
Iatrogenic	No underlying causes
Infectious Disease	CNS infection, fever
Musculoskeletal/Orthopedic	Hip cancer
Neurologic	Altitude sickness, acute, brain trauma, central neurogenic hyperventilation, cerebrovascular accident, CNS infection, cree leukoencephalopathy , damaged respiratory pathways, epilepsy, epileptic encephalopathy, early infantile, 2, head injury, intracranial space-occupying lesion, meningoencephalitis, pain, Pitt-hopkins syndrome, raised intracranial pressure, stroke, Vasovagal attacks
Nutritional/Metabolic	Diabetic ketoacidosis, hereditary fructose-1,6-bisphosphatase deficiency, heat stroke, lactic acidosis
Obstetric/Gynecologic	No underlying causes
Oncologic	Bronchial neoplasm, rib tumor
Ophthalmologic	No underlying causes
Overdose/Toxicity	Biguanide intolerance
Psychiatric	Acute stress disorder , Adult panic-anxiety syndrome, agoraphobia, anxiety , Briquet's syndrome, combat stress reaction , cree leukoencephalopathy , Crying or severe distress, Da costa syndrome, depression, distress, excitement, fear, functional disorders, grief, hypochondriasis, hysteria, malingering, pain, panic attack , phobia, primary habit disorder, Rett's syndrome, schizophrenia, stress, strong emotions
Pulmonary	Acute altitude sickness, apneustic respirations, asthma, ataxic respiration, biot's respiration, central neurogenic hyperventilation, Cheyne-stokes respirations, damaged respiratory pathways, diffuse pulmonary fibrosis, emphysema , hypocapnia,hyperventilation syndrome, inhalation of irritants, lung damage , metabolic acidosis , persistent hypoxemia, pleural effusion, pneumonia, pneumothorax, pulmonary embolism, pulmonary oedema
Renal/Electrolyte	Acid-base imbalance , metabolic acidosis , phaeochromocytoma, renal disease
Rheumatology/Immunology/Allergy	Asthma, pseudoallergic reactions
Sexual	No underlying causes
Trauma	Brain trauma, head injury, lung damage, raised intracranial pressure, sponatneous pneumothorax, stroke, surgical relocation of ureters in ileum or colon
Urologic	No underlying causes
Miscellaneous	Abdominal surgery, adulation, childbirth, fever

Causes in Alphabetical Order

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Causes

Stress or anxiety commonly are causes of hyperventilation; this is known as hyperventilation syndrome.

Hyperventilation can also be brought about voluntarily, by taking many deep breaths. Hyperventilation can also occur as a consequence of various lung diseases, head injury, coffee abuse or stroke (central neurogenic hyperventilation, apneustic respirations, ataxic respiration, Cheyne-Stokes respirations or Biot's respiration).

Lastly, in the case of metabolic acidosis, the body uses hyperventilation to counter the increased acidity of the blood; this is known as Kussmaul breathing.

• Drugs:
  • Pralidoxime
  • Tiagabine

Mechanism

In normal breathing, both the depth and frequency of breaths is varied by the neural system primarily in order to maintain normal amounts of carbon dioxide but also to supply appropriate levels of oxygen to the body's tissues. This is mainly done by measuring the carbon dioxide content of the blood; normally, a high carbon dioxide concentration signals a low oxygen concentration, as we breathe in oxygen and breathe out carbon dioxide at the same time, and the body's cells use oxygen to burn fuel molecules to carbon dioxide.

The gases in the alveoli of the lungs are nearly in equilibrium with the gases in the blood. Normally, less than 10% of the gas in the alveoli is replaced each breath. Deeper or quicker breaths exchange more of the alveolar gas with air and have the net effect of drawing more carbon dioxide out of the body, since the carbon dioxide concentration in normal air is very low.

The resulting low concentration of carbon dioxide in the blood is known as hypocapnia. Since carbon dioxide is held in the blood mostly in the form of carbonic acid, hypocapnia results in the blood becoming alkaline, i.e. the blood pH value rises. (In the normal person, this alkalosis would automatically be countered by reduced breathing, but for various reasons this doesn't happen when the neural control is not present.)

If carbon dioxide levels are high, the body assumes that oxygen levels are low, and accordingly the brain's blood vessels dilate, to assure sufficient blood flow and supply of oxygen. Conversely, low carbon dioxide levels (e.g. from hyperventilation) cause the brain's blood vessels to constrict, resulting in reduced blood flow to the brain and lightheadedness. Thus, though it seems counterintuitive, breathing too much can result in a decrease in the oxygen supply to the brain. Doctors sometimes artificially induce hyperventilation after head injury to reduce the pressure in the skull, though the treatment has potential risks.

The high pH value resulting from hyperventilation also reduces the level of available calcium (hypocalcemia), which affects the nerves and causes the numbness or tingling of the hands. This occurs because alkalinisation of the plasma proteins (mainly albumin) increases their calcium affinity.

See also

• Hypoventilation, too shallow or too slow breathing
• Control of respiration
• Respiratory alkalosis
• Shallow water blackout, the role of hyperventilation in some drowning incidents