B-cell prolymphocytic leukemia overview: Difference between revisions
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==[[B-cell prolymphocytic leukemia overview|Overview]]== | ==[[B-cell prolymphocytic leukemia overview|Overview]]== | ||
'''B-cell prolymphocytic leukemia''' is a form of [[leukemia]] or [[hematological malignancy|cancer of the white blood cells]]. Arises from mature B-cells, which are hematologic white cells that are normally involved in the in the [[humoral immunity]] component of the adaptive immune system by secreting [[antibodies]]. B-cell prolymphocytic leukemia must be differentiated from other diseases such as [[T-cell prolymphocytic leukemia]], [[chronic lymphocytic leukemia]] and [[hairy cell leukemia]]. The incidence of B-cell prolymphocytic leukemia is 1% of lymphocytic leukemias. B-cell prolymphocytic leukemia affects men and women equally. The prognosis is generally poor. Symptoms of B-cell prolymphocytic leukemia include generalised weakness and, [[anemia]], massive splenomegaly, [[weight loss]], loss of appetite, [[thrombocytopenia]] and peripheral lymphadenopathy. Common physical examination findings include [[tachycardia]], [[pallor]], [[splenomegaly]] and [[lymphadenopathy]]. Laboratory findings include [[full blood count|complete blood count]], abnormal blood chemistry studies and abnormal blood peripheral smear. B-cell prolymphocytic leukemia bone marrow biopsy is considered a definitive diagnosis. Other diagnostic studies include [[immunophenotyping]]. | '''B-cell prolymphocytic leukemia''' is a form of [[leukemia]] or [[hematological malignancy|cancer of the white blood cells]]. Arises from mature B-cells, which are hematologic white cells that are normally involved in the in the [[humoral immunity]] component of the adaptive immune system by secreting [[antibodies]]. B-cell prolymphocytic leukemia must be differentiated from other diseases such as [[T-cell prolymphocytic leukemia]], [[chronic lymphocytic leukemia]] and [[hairy cell leukemia]]. The incidence of B-cell prolymphocytic leukemia is 1% of lymphocytic leukemias. B-cell prolymphocytic leukemia affects men and women equally. The prognosis is generally poor. Symptoms of B-cell prolymphocytic leukemia include generalised weakness and, [[anemia]], massive splenomegaly, [[weight loss]], loss of appetite, [[thrombocytopenia]] and peripheral lymphadenopathy. Common physical examination findings include [[tachycardia]], [[pallor]], [[splenomegaly]] and [[lymphadenopathy]]. Laboratory findings include [[full blood count|complete blood count]], abnormal blood chemistry studies and abnormal blood peripheral smear. B-cell prolymphocytic leukemia bone marrow biopsy is considered a definitive diagnosis. Other diagnostic studies include [[immunophenotyping]]. | ||
==[[B-cell prolymphocytic leukemia historical perspective|Historical Perspective]]== | ==[[B-cell prolymphocytic leukemia historical perspective|Historical Perspective]]== | ||
Revision as of 15:28, 7 October 2015
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B-cell prolymphocytic leukemia |
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Differentiating B-cell prolymphocytic leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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B-cell prolymphocytic leukemia overview On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Carlos A Lopez, M.D. [2]
Synonyms and keywords: B-PLL, Prolymphocytic leukemia, B-cell type
Overview
B-cell prolymphocytic leukemia is a form of leukemia or cancer of the white blood cells. Arises from mature B-cells, which are hematologic white cells that are normally involved in the in the humoral immunity component of the adaptive immune system by secreting antibodies. B-cell prolymphocytic leukemia must be differentiated from other diseases such as T-cell prolymphocytic leukemia, chronic lymphocytic leukemia and hairy cell leukemia. The incidence of B-cell prolymphocytic leukemia is 1% of lymphocytic leukemias. B-cell prolymphocytic leukemia affects men and women equally. The prognosis is generally poor. Symptoms of B-cell prolymphocytic leukemia include generalised weakness and, anemia, massive splenomegaly, weight loss, loss of appetite, thrombocytopenia and peripheral lymphadenopathy. Common physical examination findings include tachycardia, pallor, splenomegaly and lymphadenopathy. Laboratory findings include complete blood count, abnormal blood chemistry studies and abnormal blood peripheral smear. B-cell prolymphocytic leukemia bone marrow biopsy is considered a definitive diagnosis. Other diagnostic studies include immunophenotyping.
Historical Perspective
Classification
Pathophysiology
B-cell prolymphocytic leukemia arises from mature B-cells, which are hematologic white cells that are normally involved in the in the humoral immunity component of the adaptive immune system by secreting antibodies.
Differentiating B-cell prolymphocytic leukemia from other Diseases
B-cell prolymphocytic leukemia must be differentiated from other diseases such as T-cell prolymphocytic leukemia, chronic lymphocytic leukemia and hairy cell leukemia.
Epidemiology and Demographics
The incidence of B-cell prolymphocytic leukemia is 1% of lymphocytic leukemias. B-cell prolymphocytic leukemia affects men and women equally.
Risk Factors
Screening
Natural History, Complications and Prognosis
The prognosis for B-cell prolymphocytic leukemia is generally poor.
Diagnosis
History and Symptoms
Symptoms of B-cell prolymphocytic leukemia include generalised weakness and, anemia, massive splenomegaly, weight loss, loss of appetite, thrombocytopenia and peripheral lymphadenopathy.
Physical Examination
Common physical examination findings of B-cell prolymphocytic leukemia include tachycardia, pallor, splenomegaly and lymphadenopathy.
Laboratory Findings
Laboratory findings consistent with the diagnosis of B-cell prolymphocytic leukemia include complete blood count, abnormal blood chemistry studies and abnormal blood peripheral smear.
Biopsy
B-cell prolymphocytic leukemia bone marrow biopsy is considered a definitive diagnosis.
Other Diagnostic Studies
Other diagnostic studies for B-cell prolymphocytic leukemia include immunophenotyping.
Medical Therapy
Chemotherapy, biological therapy, and splenectomy or radiation therapy to the spleen are indicated in the treatment of B-cell prolymphocytic leukemia.