Anaplastic large cell lymphoma classification: Difference between revisions

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:* Primary cutaneous anaplastic large cell lymphoma
:* Primary cutaneous anaplastic large cell lymphoma
:* Primary systemic anaplastic large cell lymphoma
:* Primary systemic anaplastic large cell lymphoma
===Morphologic Classification<ref>{{cite web|url=|A188154738&docType=GALE&role=|title=}}</ref>===
====Classical Variants====
====Atypical Variants====
====Rare Variants====


{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
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! style="background: #4479BA;; color:#FFF;" | Name
! style="background: #4479BA;; color:#FFF;" | Name
! style="background: #4479BA;; color:#FFF;" | Description
! style="background: #4479BA;; color:#FFF;" | Description
|-
| style="padding: 5px 5px; background: #DCDCDC;" colspan=2 | '''Classical Variants'''
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|-
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Common pattern'''
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Common pattern'''
| style="padding: 5px 5px; background: #F5F5F5;" |  
| style="padding: 5px 5px; background: #F5F5F5;" |  
* ALK positive anaplastic large cell lymphoma
* ALK positive anaplastic large cell lymphoma
|-
| style="padding: 5px 5px; background: #DCDCDC;" colspan=6 | '''Atypical Variants'''
|-
|-
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Small cell'''
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Small cell'''
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| style="padding: 5px 5px; background: #F5F5F5;" |  
| style="padding: 5px 5px; background: #F5F5F5;" |  
* ALK positive anaplastic large cell lymphoma
* ALK positive anaplastic large cell lymphoma
|-
| style="padding: 5px 5px; background: #DCDCDC;" colspan=6 | '''Rare Variants'''
|-
|-
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Sarcomatoid'''
| style="text-align: center; padding: 5px 5px; background: #F5F5F5;" |  '''Sarcomatoid'''

Revision as of 17:34, 8 October 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Anaplastic large cell lymphoma may be classified into 2 subtypes: anaplastic large cell lymphoma, ALK positive and anaplastic large cell lymphoma, ALK negative. Based on clinical presentations, anaplastic large cell lymphoma may be classified into either primary cutaneous anaplastic large cell lymphoma and primary systemic anaplastic large cell lymphoma.

Classification

  • Anaplastic large cell lymphoma (peripheral T-cell lymphoma Non-Hodgkin Lymphoma) may be classified into 2 subtypes:
  • Based on clinical presentations, anaplastic large cell lymphoma may be classified into either[1]
  • Primary cutaneous anaplastic large cell lymphoma
  • Primary systemic anaplastic large cell lymphoma
Morphologic Classification [2]
Name Description
Classical Variants
Common pattern
  • ALK positive anaplastic large cell lymphoma
Atypical Variants
Small cell
  • ALK positive anaplastic large cell lymphoma
Lymphohistiocytic
  • ALK positive anaplastic large cell lymphoma
Giant cell
  • ALK positive anaplastic large cell lymphoma
Hodgkin's like
  • ALK positive anaplastic large cell lymphoma
Rare Variants
Sarcomatoid
  • ALK positive anaplastic large cell lymphoma
Classification based on the clinical presentation[1]
Name Description
Primary cutaneous anaplastic large cell lymphoma
  • Confined to the skin
  • Usually have a single lump or tumor in the skin
  • May also spread to lymph nodes in the area
  • Associated with a rare skin condition called lymphomatoid papulosis
  • Less aggressive than primary systemic anaplastic large cell lymphoma
  • Occasionally individuals have a spontaneous remission
  • Have a fairly good prognosis
Primary systemic anaplastic large cell lymphoma
  • Usually involves the lymph nodes
  • Can also occur in organs or tissues other than the lymph nodes (extranodal sites), including:
  • lungs, liver, bone marrow, bone, gastrointestinal tract, skin and soft tissue
  • Most individuals have advanced stage (stage III or IV) disease when they are diagnosed
  • Usually a fast-growing (aggressive) lymphoma

References

  1. ↑ 1.0 1.1 Anaplastic large cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/anaplastic-large-cell-lymphoma/?region=on Accessed on October 7, 2015
  2. ↑ The anaplastic lymphoma kinase in the pathogenesis of cancer. http://go.galegroup.com/ps/retrieve.dosgHitCountType=None&sort=RELEVANCE&inPS=true&prodId=HRCA&userGroupName=mlin_b_bethidmc&tabID=T002&searchId=R1&resultListType=RESULT_LIST&contentSegment=&searchType=AdvancedSearchForm&currentPosition=1&contentSet=GALE%7CA188154738&&docId=GALE Accessed on October 8, 2015

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