Retinoblastoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Classification

MRI component	Features
Group A	Retinoblastoma 3 mm or less in basal dimension or thickness, located at least 3 mm from the foveola and 1.5 mm from the optic nerve.
Group B	Retinoblastoma not in Group A with 1 or more of the following: Macular location (≤3 mm to foveola) Juxtapapillary location (≤1.5 mm to optic nerve) Additional subretinal fluid (≤5 mm from margin).
Group C	Retinoblastoma tumor with 1 of the following: Focal subretinal seeds Focal vitreous seeds Both focal subretinal and vitreous seeds.
Group D	Retinoblastoma tumor with 1 of the following: Diffuse subretinal seeds Diffuse vitreous seeds Both diffuse subretinal and vitreous seeds.
Group E	Very high-risk eyes with 1 or more of the following: Neovascular glaucoma Massive intraocular hemorrhage Aseptic orbital cellulitis Tumor anterior to the vitreous face Tumor touching the lens Diffuse infiltrating retinoblastoma Phthisis bulbi (also known as end-stage eye, this is a nonfunctioning, atrophic, scarred, and disorganized globe, frequently with dystrophic calcification).