Ependymoma risk factors: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Ependymoma}} | {{Ependymoma}} | ||
{{CMG}} {{AE}} {{AAM}} | |||
==Overview== | |||
==Risk Factors== | |||
* Children with certain hereditary diseases, such as [[neurofibromatosis type II]] (NF2), have been found to be more frequently afflicted with ependymal tumors | |||
* increased occurrence of ''chromosome 1q'' and proteins such as [[tenascin C]] and [[epidermal growth factor]] is associated with increased risk for developing ependymal tumors. | |||
*''ERBB2'', ''ERBB4'', and human telomerase reverse transcriptase ''TERT'' gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.<ref name=Wikipedia> Ependymoma | |||
*High expression of epidermal growth factor receptor ''EGFR'' correlates with unfavorable outcome.[9] | |||
*Over-expression of [[kinetochore]] proteins and down-regulation of [[metallothionein|metallothioneins]] are associated with recurrence in ependymomas.[11] | |||
[12] | |||
*''KIT'' receptor [[tyrosine kinase]] and phospho-''KIT'' were found to be present in pediatric ependymomas and may be involved in angiogenesis associated with those tumors. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 19:10, 8 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Risk Factors
- Children with certain hereditary diseases, such as neurofibromatosis type II (NF2), have been found to be more frequently afflicted with ependymal tumors
- increased occurrence of chromosome 1q and proteins such as tenascin C and epidermal growth factor is associated with increased risk for developing ependymal tumors.
- ERBB2, ERBB4, and human telomerase reverse transcriptase TERT gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.<ref name=Wikipedia> Ependymoma
- High expression of epidermal growth factor receptor EGFR correlates with unfavorable outcome.[9]
- Over-expression of kinetochore proteins and down-regulation of metallothioneins are associated with recurrence in ependymomas.[11]
[12]
- KIT receptor tyrosine kinase and phospho-KIT were found to be present in pediatric ependymomas and may be involved in angiogenesis associated with those tumors.