Mediastinitis natural history, complications and prognosis: Difference between revisions

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Revision as of 03:11, 9 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Anthony Gallo, B.S. [2]

Overview

If left untreated, fibrosing mediastinitis may progress to sepsis and subsequently, death.^[1] Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.^[2]

Natural History

If left untreated, fibrosing mediastinitis may progress to sepsis and subsequently, death.^[1] Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.^[2]

Complications

Common complications include the following:^[1]^[3]

Sepsis
Spread of the infection to the:
- Bloodstream
- Blood vessels
- Bones
- Heart
- Lungs
Scarring
Pneumonia

Prognosis

The presence of mediastinitis among patients following chest surgery is observed to have a particularly poor prognosis; there is a serious risk of death. If treated with antibiotics, depending on the severity of the infection, prognosis is improved.^[1]

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.
↑ ^2.0 ^2.1 Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A (2011). "[Mediastinitis]". Arch Bronconeumol. 47 Suppl 8: 32–6. doi:10.1016/S0300-2896(11)70065-5. PMID 23351519.
↑ Fibrosing Mediastinitis. National Organization for Rare Disorders (2015). https://rarediseases.org/rare-diseases/fibrosing-mediastinitis/ Accessed on September 25, 2015

Template:WikiDoc Sources

[AAA-1] 1.0 ^1.1 ^1.2 ^1.3 Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.

[pmid23351519-2] 2.0 ^2.1 Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A (2011). "[Mediastinitis]". Arch Bronconeumol. 47 Suppl 8: 32–6. doi:10.1016/S0300-2896(11)70065-5. PMID 23351519.

[3] Fibrosing Mediastinitis. National Organization for Rare Disorders (2015). https://rarediseases.org/rare-diseases/fibrosing-mediastinitis/ Accessed on September 25, 2015

[1]

[2]

[3]

@@ Line 4: / Line 4: @@
 ==Overview==
-If left untreated, fibrosing mediastinitis may progress into [[sepsis]] and subsequently, death.<ref name=AAA> Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.</ref> Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.<ref name="pmid23351519">{{cite journal| author=Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A| title=[Mediastinitis]. | journal=Arch Bronconeumol | year= 2011 | volume= 47 Suppl 8 | issue=  | pages= 32-6 | pmid=23351519 | doi=10.1016/S0300-2896(11)70065-5 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23351519  }} </ref> The most severe complication is sepsis, which could result in death.
+If left untreated, fibrosing mediastinitis may progress to [[sepsis]] and subsequently, death.<ref name=AAA> Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.</ref> Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.<ref name="pmid23351519">{{cite journal| author=Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A| title=[Mediastinitis]. | journal=Arch Bronconeumol | year= 2011 | volume= 47 Suppl 8 | issue=  | pages= 32-6 | pmid=23351519 | doi=10.1016/S0300-2896(11)70065-5 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23351519  }} </ref>
 ==Natural History==
-If left untreated, fibrosing mediastinitis may progress into [[sepsis]] and subsequently, death.<ref name=AAA> Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.</ref> Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.<ref name="pmid23351519">{{cite journal| author=Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A| title=[Mediastinitis]. | journal=Arch Bronconeumol | year= 2011 | volume= 47 Suppl 8 | issue=  | pages= 32-6 | pmid=23351519 | doi=10.1016/S0300-2896(11)70065-5 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23351519  }} </ref>
+If left untreated, fibrosing mediastinitis may progress to [[sepsis]] and subsequently, death.<ref name=AAA> Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.</ref> Mortality rates related to mediastinitis vary, though some estimates predict rates greater than 60%.<ref name="pmid23351519">{{cite journal| author=Martínez Vallina P, Espinosa Jiménez D, Hernández Pérez L, Triviño Ramírez A| title=[Mediastinitis]. | journal=Arch Bronconeumol | year= 2011 | volume= 47 Suppl 8 | issue=  | pages= 32-6 | pmid=23351519 | doi=10.1016/S0300-2896(11)70065-5 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23351519  }} </ref>
 ==Complications==
 Common complications include the following:<ref name=AAA> Mediastinitis: a potentially lethal infection. Thoracics (2012). http://thoracics.org/2012/03/03/mediastinitis-noncardiac-surgery/ Accessed on September 25, 2015.</ref><ref> Fibrosing Mediastinitis. National Organization for Rare Disorders (2015). https://rarediseases.org/rare-diseases/fibrosing-mediastinitis/ Accessed on September 25, 2015</ref>
-*Development of [[sepsis]]
+*[[Sepsis]]
 *Spread of the [[infection]] to the:
 **[[Bloodstream]]