Glucagonoma history and symptoms: Difference between revisions
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*[[Necrolytic migratory erythema]] (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower [[abdomen]], [[buttock]]s, [[perineum]], and [[groin]]. | *[[Necrolytic migratory erythema]] (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower [[abdomen]], [[buttock]]s, [[perineum]], and [[groin]]. | ||
*[[Weight loss]] | *[[Weight loss]] | ||
*[[Cheilosis]] | *[[Cheilosis]] | ||
*Stomatitis | *Stomatitis | ||
*[[Diarrhea]] | *[[Diarrhea]] | ||
*Polyuria | |||
*Polydipsia | |||
*Polyphagia | |||
*Blurred vision | |||
*Lower extremity parasthesia | |||
==References== | ==References== | ||
Revision as of 15:35, 9 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
History
When evaluating a patient for glucagonoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history. Other specific areas of focus when obtaining the history include:
- Review of any family history of predisposing genetic disorders such as multiple endocrine neoplasia type 1.[1]
Symptoms
Common symptoms of glucagonoma include:[2]
- Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.
- Weight loss
- Cheilosis
- Stomatitis
- Diarrhea
- Polyuria
- Polydipsia
- Polyphagia
- Blurred vision
- Lower extremity parasthesia
References
- ↑ Glucagonoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000326.htm
- ↑ Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.