Chronic myelogenous leukemia other diagnostic studies: Difference between revisions
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==Overview== | ==Overview== | ||
Other diagnostic studies for chronic myelogenous leukemia include [[bone marrow aspiration]] and [[biopsy]], [[lumbar puncture]], and [[lymph node biopsy]]. | Other diagnostic studies for chronic myelogenous leukemia include [[bone marrow aspiration]] and [[biopsy]], [[lumbar puncture]], and [[lymph node biopsy]]. | ||
== | ==Other diagnostic studies== | ||
Other diagnostic studies for chronic myelogenous leukemia include: | |||
*[[Bone marrow aspiration]] and [[biopsy]] | |||
:*Used to detect and/or determine the type of leukemic cells | |||
*[[Lumbar puncture]] | |||
:*Used to detect any metastasis to the [[cerebral spinal fluid]] (CSF) | |||
*[[Lymph node biopsy]] | |||
:*Used to detect and/or determine the type of leukemic cells | |||
[[Image:CDR533336-571.jpg|thumb|left|200px|[[Philadelphia chromosome]]. A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The bcr-abl gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the [[Philadelphia chromosome]]{{-}} | [[Image:CDR533336-571.jpg|thumb|left|200px|[[Philadelphia chromosome]]. A piece of chromosome 9 and a piece of chromosome 22 break off and trade places. The bcr-abl gene is formed on chromosome 22 where the piece of chromosome 9 attaches. The changed chromosome 22 is called the [[Philadelphia chromosome]]{{-}} | ||
Revision as of 15:35, 9 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Other diagnostic studies for chronic myelogenous leukemia include bone marrow aspiration and biopsy, lumbar puncture, and lymph node biopsy.
Other diagnostic studies
Other diagnostic studies for chronic myelogenous leukemia include:
- Used to detect and/or determine the type of leukemic cells
- Used to detect any metastasis to the cerebral spinal fluid (CSF)
- Used to detect and/or determine the type of leukemic cells
Controversy exists over so-called Ph-negative CML, or cases of suspected CML in which the Philadelphia chromosome cannot be detected. Many such patients in fact have complex chromosomal abnormalities which mask the (9;22) translocation, or have evidence of the translocation by FISH or RT-PCR in spite of normal routine karyotyping.[1] The small subset of patients without detectable molecular evidence of bcr-abl fusion may be better classified as having an undifferentiated myelodysplastic/myeloproliferative disorder, as their clinical course tends to be different from patients with CML.[2]
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Chronic myelogenous leukemia
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Chronic myelogenous leukemia
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Chronic myelomonocytic leukemia ( CMMoL)
Gallery
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![Blast crisis of chronic myelogenous leukemia (CML). From Public Health Image Library (PHIL). [3]](/images/5/54/Human_herpesvirus03.jpeg)
Blast crisis of chronic myelogenous leukemia (CML). From Public Health Image Library (PHIL). [3]
![Blast crisis of chronic myelogenous leukemia (CML). From Public Health Image Library (PHIL). [3]](/index.php/File:Human_herpesvirus03.jpeg)
References
- ↑ Savage DG; Szydlo RM; Goldman JM (1997). "Clinical features at diagnosis in 430 patients with chronic myeloid leukaemia seen at a referral centre over a 16-year period". Br J Haematol. 96 (1): 111–116. PMID 9012696.
- ↑ Tefferi A, Thiele J, Orazi A, Kvasnicka HM, Barbui T, Hanson CA, Barosi G, Verstovsek S, Birgegard G, Mesa R, Reilly JT, Gisslinger H, Vannucchi AM, Cervantes F, Finazzi G, Hoffman R, Gilliland DG, Bloomfield CD, Vardiman JW (2007). "Proposals and rationale for revision of the World Health Organization diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis: recommendations from an ad hoc international expert pane". Blood. 110 (4): 1092–1097. PMID 17488875.
- ↑ "Public Health Image Library (PHIL)".