Glucagonoma surgery: Difference between revisions
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==Surgery== | ==Surgery== | ||
Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692 }} </ref> | Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.<ref name="pmid15313692">{{cite journal| author=Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS| title=Clinical experience in diagnosis and treatment of glucagonoma syndrome. | journal=Hepatobiliary Pancreat Dis Int | year= 2004 | volume= 3 | issue= 3 | pages= 473-5 | pmid=15313692 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15313692 }} </ref> | ||
Single, small lesion in head or tail of pancreas:[1-4] | |||
: | Enucleation, if feasible. | ||
Large lesion in the head of the pancreas that is not amenable to enucleation:[1-4] | |||
Pancreaticoduodenectomy. | |||
Single, large lesion in body/tail:[1-4] | |||
Distal pancreatectomy. | |||
Multiple lesions:[1-4] | |||
Enucleation, if feasible. | |||
Resect body and tail otherwise. | |||
Metastatic disease: lymph nodes or distant sites:[5-12] | |||
Resect when possible. | |||
Consider radiofrequency or cryosurgical ablation, if not resectable. | |||
Unresectable disease:[13-22] | |||
Combination chemotherapy. | |||
Somatostatin analogue therapy. Necrotizing erythema of glucagonoma may be relieved in 24 hours with somatostatin analogue, with nearly complete disappearance within 1 week. | |||
==References== | ==References== | ||
Revision as of 17:23, 9 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.[1]
Surgery
Surgery is the mainstay of treatment for glucagonoma. The feasibility of surgery depends on the stage of glucagonoma at diagnosis.[1] Single, small lesion in head or tail of pancreas:[1-4]
Enucleation, if feasible.
Large lesion in the head of the pancreas that is not amenable to enucleation:[1-4]
Pancreaticoduodenectomy.
Single, large lesion in body/tail:[1-4]
Distal pancreatectomy.
Multiple lesions:[1-4]
Enucleation, if feasible. Resect body and tail otherwise.
Metastatic disease: lymph nodes or distant sites:[5-12]
Resect when possible. Consider radiofrequency or cryosurgical ablation, if not resectable.
Unresectable disease:[13-22]
Combination chemotherapy. Somatostatin analogue therapy. Necrotizing erythema of glucagonoma may be relieved in 24 hours with somatostatin analogue, with nearly complete disappearance within 1 week.
References
- ↑ 1.0 1.1 Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS (2004). "Clinical experience in diagnosis and treatment of glucagonoma syndrome". Hepatobiliary Pancreat Dis Int. 3 (3): 473–5. PMID 15313692.