Ependymoma risk factors: Difference between revisions
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{{CMG}} {{AE}} {{AAM}} | {{CMG}} {{AE}} {{AAM}} | ||
==Overview== | ==Overview== | ||
Common risk factors in the development of ependymoma are children with certain hereditary diseases (neurofibromatosis type II and Turcot syndrome), ''ERBB2'', ''ERBB4'', and human telomerase reverse transcriptase ''TERT'' gene expression, over-expression of [[kinetochore]] proteins, and down-regulation of [[metallothionein|metallothioneins]]. | Common risk factors in the development of ependymoma are children with certain hereditary diseases ([[neurofibromatosis]] type II and Turcot syndrome), ''ERBB2'', ''ERBB4'', and human telomerase reverse transcriptase ''TERT'' gene expression, over-expression of [[kinetochore]] proteins, and down-regulation of [[metallothionein|metallothioneins]]. | ||
==Risk Factors== | ==Risk Factors== | ||
* Children with certain hereditary diseases, such as [[neurofibromatosis type II]] (NF2), [[Turcot syndrome]] B, and [[MEN1 syndrome]], have been found to be more frequently afflicted with ependymal tumors | * Children with certain hereditary diseases, such as [[neurofibromatosis type II]] (NF2), [[Turcot syndrome]] B, and [[MEN1 syndrome]], have been found to be more frequently afflicted with ependymal tumors | ||
Revision as of 20:41, 9 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Common risk factors in the development of ependymoma are children with certain hereditary diseases (neurofibromatosis type II and Turcot syndrome), ERBB2, ERBB4, and human telomerase reverse transcriptase TERT gene expression, over-expression of kinetochore proteins, and down-regulation of metallothioneins.
Risk Factors
- Children with certain hereditary diseases, such as neurofibromatosis type II (NF2), Turcot syndrome B, and MEN1 syndrome, have been found to be more frequently afflicted with ependymal tumors
- increased occurrence of chromosome 1q and proteins such as tenascin C and epidermal growth factor is associated with increased risk for developing ependymal tumors.
- ERBB2, ERBB4, and human telomerase reverse transcriptase TERT gene expression promote tumor cell proliferation, contributing to aggressive tumor behavior.[1]
- High expression of epidermal growth factor receptor EGFR correlates with unfavorable outcome.[2]
- Over-expression of kinetochore proteins and down-regulation of metallothioneins are associated with recurrence in ependymomas.[3]
References
- ↑ Ependymoma https://en.wikipedia.org/wiki/Pediatric_ependymoma#Cell_of_origin. URL Accessed on 10 08 2015
- ↑ Mendrzyk F, Korshunov A, Benner A, Toedt G, Pfister S, Radlwimmer B; et al. (2006). "Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in intracranial ependymoma". Clin Cancer Res. 12 (7 Pt 1): 2070–9. doi:10.1158/1078-0432.CCR-05-2363. PMID 16609018.
- ↑ Peyre M, Commo F, Dantas-Barbosa C, Andreiuolo F, Puget S, Lacroix L; et al. (2010). "Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis". PLoS One. 5 (9): e12932. doi:10.1371/journal.pone.0012932. PMC 2945762. PMID 20885975.