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Haytham Allaham (talk | contribs)
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Haytham Allaham (talk | contribs)
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Line 19: Line 19:
*'''DNA index >1'''<br>
*'''DNA index >1'''<br>
*'''''MYCN'' not amplified'''</div>}}
*'''''MYCN'' not amplified'''</div>}}
{{familytree/end}}
<br>
{{familytree/start |summary=PE diagnosis Algorithm.}}
{{familytree | | | | | | | | | | | | | | |,| B03 | | | | |B03= }}
{{familytree | | | | | | | | | | | | | | |!| | | | | | | | | | | | | }}
{{familytree | | | | | | | | | | | | | | |)| B05 | | | | | B05= | | | | | | }}
{{familytree | | | | | | | | | |,|-| B01 |(| | | | | | | B01= | | | | | | }}
{{familytree | | | | | | | | | |!| | | | |)| B02 | | | | | |B02= }}
{{familytree | | | | | | | | | |!| | | | |!| | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |!| | | | |`| B04 | | | | | B04= | | | | | }}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | C01 |-|+|-| C02 |-| C03 | | | |C01= |C02= |C03= }}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | | | | |`|-| D01 |-| D02 | | | |D01= |D02= }}
{{familytree/end}}
Intermediate risk neuroblastoma patients include:
Group 1
Patients with stage 2A/2B (<50% resected or Bx only) tumor, 0-12 years of age, irrespective of the grade, MYCNnot amplified
Patients with stage 3 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified
Patients with stage 3 tumor, 1-12 years of age, favorable histology, MYCNnot amplified
Patients with symptomatic stage 4S, <365 days of age, favorable histology, DNA index >1, MYCNnot amplified
Group 2
Patients with stage 3 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified
Patients with stage 4 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified
Patients with stage 4S tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified
Group 3
Patients with stage 4 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified
Patients with stage 3 tumor, 365-547 days of age, unfavorable histology, MYCN not amplified
Patients with stage 4 tumor, 365-547 days of age, favorable histology, DNA index >1, MYCN not amplified

Revision as of 01:40, 10 October 2015

 
 
 
 
 
 
 
 
 
 
 
 
  • INSS stage 1
  • Irrespective of age
  • Irrespective of grade
  • Irrespective of molecular pathway
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Low risk neuroblastoma patients
 
 
 
 
  • INSS stage 2A/2B (>50% resected)
  • Irrespective of age
  • Irrespective of grade
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INNS stage 4S
  • <365 days of age
  • Favorable histology
  • DNA index >1
  • MYCN not amplified
 
 
 
 
 
 
 
 


 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 



Intermediate risk neuroblastoma patients include:

Group 1

Patients with stage 2A/2B (<50% resected or Bx only) tumor, 0-12 years of age, irrespective of the grade, MYCNnot amplified Patients with stage 3 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified Patients with stage 3 tumor, 1-12 years of age, favorable histology, MYCNnot amplified Patients with symptomatic stage 4S, <365 days of age, favorable histology, DNA index >1, MYCNnot amplified

Group 2

Patients with stage 3 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified Patients with stage 4 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified Patients with stage 4S tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified

Group 3

Patients with stage 4 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified Patients with stage 3 tumor, 365-547 days of age, unfavorable histology, MYCN not amplified Patients with stage 4 tumor, 365-547 days of age, favorable histology, DNA index >1, MYCN not amplified