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{{familytree/start |summary=PE diagnosis Algorithm.}}
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{{familytree | | | | | | | | | |,|-| A01 | | | | |A01=
<div style="width: 20em; padding:0em;text-align:left">
* '''INSS stage 1'''<br>
*'''Irrespective of age'''<br>
*'''Irrespective of grade'''<br>
*'''Irrespective of molecular pathway'''</div>}}
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{{familytree | | | | | | | | | |)|-| B01 | | | | ||B01=<div style="width: 20em; padding:0em;text-align:left">
*'''INSS stage 2A/2B (>50% resected)'''<br>
*'''Irrespective of age'''<br>
*'''Irrespective of grade'''<br>
*'''''MYCN'' not amplified'''</div>}}
{{familytree | | | | | | | | | |!| | | | | | | | | | | | | | | | | }}
{{familytree | | | | | | C01 |-|(| | | | | |C01=<div style="width: 20em; padding:1em;text-align:center">'''Intermediate risk neuroblastoma patients (group 1)'''</div> | | | | | | | | | | | | }}
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{{familytree | | | | | | | | | |)|-| C02 | | | | | | |C02=<div style="width: 20em; padding:0em;text-align:left">
*'''INNS stage 4S'''<br>
*'''<365 days of age'''<br>
*'''Favorable histology'''<br>
*'''DNA index >1'''<br>
*'''''MYCN'' not amplified'''</div>}}
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*'''INNS stage 4S'''<br>
*'''<365 days of age'''<br>
*'''Favorable histology'''<br>
*'''DNA index >1'''<br>
*'''''MYCN'' not amplified'''</div>}}
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{{familytree/start |summary=PE diagnosis Algorithm.}}
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Revision as of 02:23, 10 October 2015

 
 
 
 
 
 
 
 
 
 
 
 
  • INSS stage 1
  • Irrespective of age
  • Irrespective of grade
  • Irrespective of molecular pathway
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Low risk neuroblastoma patients
 
 
 
 
  • INSS stage 2A/2B (>50% resected)
  • Irrespective of age
  • Irrespective of grade
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INNS stage 4S
  • <365 days of age
  • Favorable histology
  • DNA index >1
  • MYCN not amplified
 
 
 
 
 
 
 
 


 
 
 
 
 
 
 
 
 
 
 
 
  • INSS stage 1
  • Irrespective of age
  • Irrespective of grade
  • Irrespective of molecular pathway
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INSS stage 2A/2B (>50% resected)
  • Irrespective of age
  • Irrespective of grade
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Intermediate risk neuroblastoma patients (group 1)
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INNS stage 4S
  • <365 days of age
  • Favorable histology
  • DNA index >1
  • MYCN not amplified
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
  • INNS stage 4S
  • <365 days of age
  • Favorable histology
  • DNA index >1
  • MYCN not amplified
 
 
 
 
 
 
 
 




Intermediate risk neuroblastoma patients include:

Group 1

Patients with stage 2A/2B (<50% resected or Bx only) tumor, 0-12 years of age, irrespective of the grade, MYCNnot amplified Patients with stage 3 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified Patients with stage 3 tumor, 1-12 years of age, favorable histology, MYCNnot amplified Patients with symptomatic stage 4S, <365 days of age, favorable histology, DNA index >1, MYCNnot amplified

Group 2

Patients with stage 3 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified Patients with stage 4 tumor, <365 days of age, favorable histology, DNA index >1, MYCN not amplified Patients with stage 4S tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified

Group 3

Patients with stage 4 tumor, <365 days of age, unfavorable histology, DNA index=1, MYCN not amplified Patients with stage 3 tumor, 365-547 days of age, unfavorable histology, MYCN not amplified Patients with stage 4 tumor, 365-547 days of age, favorable histology, DNA index >1, MYCN not amplified