Optic nerve glioma causes: Difference between revisions
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There is no established cause for optic nerve glioma. | There is no established cause for optic nerve glioma. | ||
==Causes== | ==Causes== | ||
*There is no established cause for optic nerve glioma. | *There is no established cause for optic nerve glioma. | ||
*Sporadic pilocytic astrocytomas usually have a tandem duplication of chromosome 7q34 and associated ''BRAF-KIAA'' fusion gene.<ref name="pmid19603027">{{cite journal| author=Jacob K, Albrecht S, Sollier C, Faury D, Sader E, Montpetit A et al.| title=Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. | journal=Br J Cancer | year= 2009 | volume= 101 | issue= 4 | pages= 722-33 | pmid=19603027 | doi=10.1038/sj.bjc.6605179 | pmc=PMC2736806 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19603027 }} </ref><ref name="pmid19794125">{{cite journal| author=Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA et al.| title=Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. | journal=Neurology | year= 2009 | volume= 73 | issue= 19 | pages= 1526-31 | pmid=19794125 | doi=10.1212/WNL.0b013e3181c0664a | pmc=PMC2777068 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19794125 }} </ref> Pilocytic astrocytomas associated with [[neurofibromatosis]] type 1 lack this fusion gene. However, it is unknown if the mutation in the ''BRAF-KIAA'' fusion gene in the setting of optic nerve glioma is the primary cause of the disease as it is in other pilocystic astrocytomas. | *Sporadic pilocytic astrocytomas usually have a tandem duplication of chromosome 7q34 and associated ''BRAF-KIAA'' fusion gene.<ref name="pmid19603027">{{cite journal| author=Jacob K, Albrecht S, Sollier C, Faury D, Sader E, Montpetit A et al.| title=Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours. | journal=Br J Cancer | year= 2009 | volume= 101 | issue= 4 | pages= 722-33 | pmid=19603027 | doi=10.1038/sj.bjc.6605179 | pmc=PMC2736806 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19603027 }} </ref><ref name="pmid19794125">{{cite journal| author=Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA et al.| title=Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. | journal=Neurology | year= 2009 | volume= 73 | issue= 19 | pages= 1526-31 | pmid=19794125 | doi=10.1212/WNL.0b013e3181c0664a | pmc=PMC2777068 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19794125 }} </ref> Pilocytic astrocytomas associated with [[neurofibromatosis]] type 1 lack this fusion gene. However, it is unknown if the mutation in the ''BRAF-KIAA'' fusion gene in the setting of optic nerve glioma is the primary cause of the disease as it is in other pilocystic astrocytomas. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
There is no established cause for optic nerve glioma.
Causes
- There is no established cause for optic nerve glioma.
- Sporadic pilocytic astrocytomas usually have a tandem duplication of chromosome 7q34 and associated BRAF-KIAA fusion gene.[1][2] Pilocytic astrocytomas associated with neurofibromatosis type 1 lack this fusion gene. However, it is unknown if the mutation in the BRAF-KIAA fusion gene in the setting of optic nerve glioma is the primary cause of the disease as it is in other pilocystic astrocytomas.
References
- ↑ Jacob K, Albrecht S, Sollier C, Faury D, Sader E, Montpetit A; et al. (2009). "Duplication of 7q34 is specific to juvenile pilocytic astrocytomas and a hallmark of cerebellar and optic pathway tumours". Br J Cancer. 101 (4): 722–33. doi:10.1038/sj.bjc.6605179. PMC 2736806. PMID 19603027.
- ↑ Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA; et al. (2009). "Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma". Neurology. 73 (19): 1526–31. doi:10.1212/WNL.0b013e3181c0664a. PMC 2777068. PMID 19794125.