Retinoblastoma pathophysiology: Difference between revisions
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==Gross Pathology== | ==Gross Pathology== | ||
Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas. Macroscopic examination reveals a white elevated mass with fine surface vessels. Early retinoblastoma presents as a solitary or multifocal, well-circumscribed translucent mass. The tumor becomes more pink in color, with dilated feeding blood vessels, as the disease advances. The tumor may exhibit three patterns of growth: | Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas. Macroscopic examination reveals a white elevated mass with fine surface vessels. Early retinoblastoma presents as a solitary or multifocal, well-circumscribed translucent mass. The tumor becomes more pink in color, with dilated feeding blood vessels, as the disease advances. The tumor may exhibit three patterns of growth: | ||
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Growth patterns}} | |||
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:Endophytic | |||
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*Growth occurs inwards into the vitreous | |||
*Cell clusters may detach and float in the vitreous (vitreous seeding) | |||
*Tumor cells can enter the anterior chamber and layer behind the cornea, causing a pseudo-hypopyon. | |||
*Spontaneous necrosis of the tumor can lead to a severe intraocular inflammatory response, presenting as pseudo-endophthalmitis. | |||
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:Exophytic | |||
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*Growth occurs outwards toward choroid | |||
*Associated with non-rhegmatogeneous retinal detachment | |||
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:Combined endophytic and exophytic | |||
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*Mixed components of endophytic and exophytic are seen | |||
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==See also== | ==See also== | ||
*[[Eye cancer]] | *[[Eye cancer]] | ||
Revision as of 18:20, 10 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Retinoblastoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Retinoblastoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Retinoblastoma pathophysiology |
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Risk calculators and risk factors for Retinoblastoma pathophysiology |
Overview
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. On microscopic histopathological analysis, [feature1], [feature2], and feature3] are characteristic findings of [disease name].
Gross Pathology
Macroscopically, viable tumor cells are found near blood vessels, while zones of necrosis are found in relatively avascular areas. Macroscopic examination reveals a white elevated mass with fine surface vessels. Early retinoblastoma presents as a solitary or multifocal, well-circumscribed translucent mass. The tumor becomes more pink in color, with dilated feeding blood vessels, as the disease advances. The tumor may exhibit three patterns of growth:
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