Anaplastic large cell lymphoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
Anaplastic large cell lymphoma may be classified into | |||
Anaplastic large cell lymphoma may be classified into several subtypes based on clinical presentation and histology. | |||
==Classification== | ==Classification== | ||
* Anaplastic large cell lymphoma (peripheral T-cell lymphoma [[Non-Hodgkin Lymphoma]]) may be classified into 2 subtypes: | * Anaplastic large cell lymphoma (peripheral T-cell lymphoma [[Non-Hodgkin Lymphoma]]) may be classified into 2 subtypes: | ||
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* ALK positive anaplastic large cell lymphoma | * ALK positive anaplastic large cell lymphoma | ||
* Cells have nuclear irregularity and perivascular/intravascular distribution | * Cells have nuclear irregularity and perivascular/intravascular distribution<ref name="pmid8394652">{{cite journal| author=Kinney MC, Collins RD, Greer JP, Whitlock JA, Sioutos N, Kadin ME| title=A small-cell-predominant variant of primary Ki-1 (CD30)+ T-cell lymphoma. | journal=Am J Surg Pathol | year= 1993 | volume= 17 | issue= 9 | pages= 859-68 | pmid=8394652 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8394652 }}</ref> | ||
* Occasionally, lymphomatous cells have a pale cytoplasm with a central nucleus, described as "fried egg cell"<ref name=Swerdlow>{{cite book | last = Swerdlow | first = Steven | title = WHO classification of tumours of haematopoietic and lymphoid tissues | publisher = International Agency for Research on Cancer | location = Lyon, France | year = 2008 | isbn = 9789283224310 }}</ref> | * Occasionally, lymphomatous cells have a pale cytoplasm with a central nucleus, described as "fried egg cell"<ref name=Swerdlow>{{cite book | last = Swerdlow | first = Steven | title = WHO classification of tumours of haematopoietic and lymphoid tissues | publisher = International Agency for Research on Cancer | location = Lyon, France | year = 2008 | isbn = 9789283224310 }}</ref> | ||
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Revision as of 13:01, 13 October 2015
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Anaplastic large cell lymphoma Microchapters |
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Differentiating Anaplastic large cell lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Anaplastic large cell lymphoma may be classified into several subtypes based on clinical presentation and histology.
Classification
- Anaplastic large cell lymphoma (peripheral T-cell lymphoma Non-Hodgkin Lymphoma) may be classified into 2 subtypes:
- Based on clinical presentations, anaplastic large cell lymphoma may be classified into either[1]
- Primary cutaneous anaplastic large cell lymphoma
- Primary systemic anaplastic large cell lymphoma
- Based on histology, anaplastic large cell lymphoma may be classified into 3 subtypes:
- Classical Variants
- Atypical Variants
- Rare Variants
| Name | Description |
|---|---|
| Primary cutaneous anaplastic large cell lymphoma |
|
| Primary systemic anaplastic large cell lymphoma |
|
| Name | Description | ||||
|---|---|---|---|---|---|
| Classical Variants | |||||
| Common pattern |
| ||||
| Atypical Variants | |||||
| Small cell | |||||
| Lymphohistiocytic |
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| Giant cell |
| ||||
| Hodgkin's like |
| ||||
| Rare Variants | |||||
| Sarcomatoid |
| ||||
References
- ↑ 1.0 1.1 Anaplastic large cell lymphoma. Canadian Cancer Society. http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/non-hodgkin-lymphoma/types-of-nhl/anaplastic-large-cell-lymphoma/?region=on Accessed on October 7, 2015
- ↑ The anaplastic lymphoma kinase in the pathogenesis of cancer. http://go.galegroup.com/ps/retrieve.dosgHitCountType=None&sort=RELEVANCE&inPS=true&prodId=HRCA&userGroupName=mlin_b_bethidmc&tabID=T002&searchId=R1&resultListType=RESULT_LIST&contentSegment=&searchType=AdvancedSearchForm¤tPosition=1&contentSet=GALE%7CA188154738&&docId=GALE Accessed on October 8, 2015
- ↑ 3.0 3.1 3.2 Swerdlow, Steven (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer. ISBN 9789283224310.
- ↑ Falini B, Bigerna B, Fizzotti M, Pulford K, Pileri SA, Delsol G; et al. (1998). "ALK expression defines a distinct group of T/null lymphomas ("ALK lymphomas") with a wide morphological spectrum". Am J Pathol. 153 (3): 875–86. doi:10.1016/S0002-9440(10)65629-5. PMC 1853018. PMID 9736036.
- ↑ Kinney MC, Collins RD, Greer JP, Whitlock JA, Sioutos N, Kadin ME (1993). "A small-cell-predominant variant of primary Ki-1 (CD30)+ T-cell lymphoma". Am J Surg Pathol. 17 (9): 859–68. PMID 8394652.
- ↑ "Frequent Expression ofthe NPM-ALK Chimeric Fusion Protein inAnaplastic Large-Cell Lymphoma, Lympho-Histiocytic Type" (PDF).
- ↑ 7.0 7.1 Vassallo J, Lamant L, Brugieres L, Gaillard F, Campo E, Brousset P; et al. (2006). "ALK-positive anaplastic large cell lymphoma mimicking nodular sclerosis Hodgkin's lymphoma: report of 10 cases". Am J Surg Pathol. 30 (2): 223–9. PMID 16434897.