Glucagonoma history and symptoms: Difference between revisions
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Image:Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area..jpg|Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area.<ref name="pmid25029913">{{cite journal| author=Wu SL, Bai JG, Xu J, Ma QY, Wu Z| title=Necrolytic migratory erythema as the first manifestation of pancreatic neuroendocrine tumor. | journal=World J Surg Oncol | year= 2014 | volume= 12 | issue= | pages= 220 | pmid=25029913 | doi=10.1186/1477-7819-12-220 | pmc=PMC4105234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25029913 }} </ref> | |||
==References== | ==References== | ||
Revision as of 15:30, 13 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Symptoms of glucagonoma include necrolytic migratory erythema, cheilosis, stomatitis, diarrhea, polyuria, and polydipsia. A positive family history of multiple endocrine neoplasia type 1 may be present.
History
When evaluating a patient for glucagonoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history. Other specific areas of focus when obtaining the history include:
- Review of any family history of predisposing genetic disorders such as multiple endocrine neoplasia type 1.[1]
Symptoms
Common symptoms of glucagonoma include:[2]
- Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.
- Weight loss
- Cheilosis
- Stomatitis
- Diarrhea
- Polyphagia
- Blurred vision
- Lower extremity parasthesia
Image
Image:Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area..jpg|Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area.[3]
References
- ↑ Glucagonoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000326.htm
- ↑ Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.
- ↑ Wu SL, Bai JG, Xu J, Ma QY, Wu Z (2014). "Necrolytic migratory erythema as the first manifestation of pancreatic neuroendocrine tumor". World J Surg Oncol. 12: 220. doi:10.1186/1477-7819-12-220. PMC 4105234. PMID 25029913.