Oligodendroglioma other diagnostic studies: Difference between revisions

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Revision as of 19:09, 13 October 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Other diagnostic studies for oligodendroglioma include biopsy and fluorescent in-situ hybridization (FISH) technique.

On biopsy, oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus, giving them a “fried egg” appearance.^[1]
Biopsy may be done at the time of surgical resection of oligodendroglioma.
Biopsy may be performed to help confirm the diagnosis of oligodendroglioma.
Biopsy may be of two types: open and stereotactic.
Indications for open biopsy and stereotactic biopsy are described below:^[2]


Type of biopsy	Indications

Open biopsy	Surgically resectable masses Lesions in accessible and relatively “silent” areas of the brain or in areas of the brain with a mild postoperative neurologic deficit Appearance consistent with tumor on the MRI Large tumors exerting mass effect
Stereotactic biopsy	Deep-seated tumor that is not amenable to resection Lesions in which the radiological and clinical findings are ambiguous Diffuse lesions; multiple lesions; an appearance that suggests a lymphoma, which would not require resection Change in the appearance of a previously diagnosed or treated tumor Assessment of tumor after treatment (to distinguish between radiation necrosis and tumor recurrence)

@@ Line 8: / Line 8: @@
 ==Other Diagnostic Studies==
 ===Biopsy===
-*On [[biopsy]], oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus, giving them a “''fried egg''” appearance.
+*On [[biopsy]], oligodendroglioma is characterized by homogeneous, compact, rounded cells with distinct borders and clear cytoplasm surrounding a dense central nucleus, giving them a “''fried egg''” appearance.<ref name="pmid25943885">{{cite journal| author=Wesseling P, van den Bent M, Perry A| title=Oligodendroglioma: pathology, molecular mechanisms and markers. | journal=Acta Neuropathol | year= 2015 | volume= 129 | issue= 6 | pages= 809-27 | pmid=25943885 | doi=10.1007/s00401-015-1424-1 | pmc=PMC4436696 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25943885  }} </ref>
 *Biopsy may be done at the time of [[surgical resection]] of oligodendroglioma.
 *Biopsy may be performed to help confirm the diagnosis of oligodendroglioma.