Oligodendroglioma other imaging findings: Difference between revisions
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===Bone Scan=== | ===Bone Scan=== | ||
*Most malignant gliomas get metastasized to the bones via the hematogenous spread.<ref name="pmid24212625">{{cite journal| author=Beauchesne P| title=Extra-neural metastases of malignant gliomas: myth or reality? | journal=Cancers (Basel) | year= 2011 | volume= 3 | issue= 1 | pages= 461-77 | pmid=24212625 | doi=10.3390/cancers3010461 | pmc=PMC3756372 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24212625 }} </ref> | *Most malignant gliomas get metastasized to the bones via the hematogenous spread.<ref name="pmid24212625">{{cite journal| author=Beauchesne P| title=Extra-neural metastases of malignant gliomas: myth or reality? | journal=Cancers (Basel) | year= 2011 | volume= 3 | issue= 1 | pages= 461-77 | pmid=24212625 | doi=10.3390/cancers3010461 | pmc=PMC3756372 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24212625 }} </ref> | ||
*[[Bone scan]] may be performed to detect metastases of malignant oligodendroglioma to [[bones]].<ref name="pmid16219856">{{cite journal| author=Al-Ali F, Hendon AJ, Liepman MK, Wisniewski JL, Krinock MJ, Beckman K| title=Oligodendroglioma metastatic to bone marrow. | journal=AJNR Am J Neuroradiol | year= 2005 | volume= 26 | issue= 9 | pages= 2410-4 | pmid=16219856 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16219856 }} </ref> | *[[Bone scan]] may be performed to detect metastases of malignant oligodendroglioma to [[bones]].<ref name="pmid16219856">{{cite journal| author=Al-Ali F, Hendon AJ, Liepman MK, Wisniewski JL, Krinock MJ, Beckman K| title=Oligodendroglioma metastatic to bone marrow. | journal=AJNR Am J Neuroradiol | year= 2005 | volume= 26 | issue= 9 | pages= 2410-4 | pmid=16219856 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16219856 }} </ref><ref name="pmid8580060">{{cite journal| author=Gerrard GE, Bond MG, Jack AS| title=Bone marrow infiltration by a parietal lobe grade III oligodendroglioma. | journal=Clin Oncol (R Coll Radiol) | year= 1995 | volume= 7 | issue= 5 | pages= 321-2 | pmid=8580060 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8580060 }} </ref> | ||
==References== | ==References== | ||
Revision as of 23:26, 13 October 2015
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Oligodendroglioma Microchapters |
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Oligodendroglioma other imaging findings On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Other Imaging Findings
Other imaging studies for oligodendroglioma include MR spectroscopy, MR perfusion, PET scan, and bone scan.
Magnetic Resonance Spectroscopy
- Findings on MR spectroscopy include:[1][2][3][4]
- N-acetyl aspartate (NAA) peak is dominant
- Choline-to-creatine ratio of less than 3:1
- Reduction of NAA/creatine ratio
- Increased choline levels and decreased NAA levels with a myo-inositol peak
- Increased glutamine and glutamate levels in low-grade oligodendroglioma in contrast to high-grade oligodendroglioma
- Increased lipid and lactate levels in high-grade oligodendroglioma in contrast to low-grade oligodendroglioma
Images
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![On spectroscopy, the lesion demonstrates increased choline and decreased NAA with a myo-inositol peak.[5]](/images/0/03/MRS_oligodendroglioma.jpeg)
On spectroscopy, the lesion demonstrates increased choline and decreased NAA with a myo-inositol peak.[5]
![On spectroscopy, the lesion demonstrates increased choline and decreased NAA with a myo-inositol peak.[5]](/index.php/File:MRS_oligodendroglioma.jpeg)
Magnetic Resonance Perfusion
- Findings on MR perfusion include:[6]
- Increased "chicken wire" network of vascularity, which results in elevated relative cerebral blood volume (rCBV)
- MR perfusion has a sensitivity of 95% for distinguishing grade II from grade III oligodendrogliomas. rCBV above the threshold of 1.75 demonstrates more rapid tumor progression.
Images
-
![MR perfusion demonstrates significantly increased CBV (area 'under' the purple curve) compared to the other side.[7]](/images/7/76/MR_perfusion_oligodendroglioma_1.jpg)
MR perfusion demonstrates significantly increased CBV (area 'under' the purple curve) compared to the other side.[7] -
![MR perfusion of the brain.[7]](/images/0/0c/MR_perfusion_oligodendroglioma_2.jpg)
MR perfusion of the brain.[7]
![MR perfusion demonstrates significantly increased CBV (area 'under' the purple curve) compared to the other side.[7]](/index.php/File:MR_perfusion_oligodendroglioma_1.jpg)
![MR perfusion of the brain.[7]](/index.php/File:MR_perfusion_oligodendroglioma_2.jpg)
Positron Emission Tomography
- 11C-Methionine PET and F-18 FDG PET studies can be used to differentiate oligodendroglioma from anaplastic oligodendroglioma.[6]
- [18F]fluorodeoxyglucose PET scan has been helpful in:[6][8]
- Differeniating oligodendroglioma from anaplastic oligodendroglioma - [18F] fluorodeoxyglucose (FDG) uptake of oligodendroglioma is similar to normal white matter, whereas FDG uptake of anaplastic oligodendroglioma is similar to normal gray matter
- Differentiating tumor recurrence from tumor necrosis
- Therapy response assessment
Bone Scan
- Most malignant gliomas get metastasized to the bones via the hematogenous spread.[9]
- Bone scan may be performed to detect metastases of malignant oligodendroglioma to bones.[10][11]
References
- ↑ Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN (2004). "Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion". N Engl J Med. 351 (18): 1875–82. doi:10.1056/NEJMcpc049025. PMID 15509821.
- ↑ Nikaido K, Nihira H, Wakai S, Honmo O, Tsuzuki A (2003). "[A case of oligodendroglioma with temporal lobe epilepsy initially suspected as having paroxymal tachycardia]". No To Hattatsu. 35 (5): 401–5. PMID 13677949.
- ↑ Axial MRS of oligodendroglioma. Dr. Bruno Di Muzio. Radiopaedia 2015. http://radiopaedia.org/cases/oligodendroglioma-14
- ↑ Rijpkema M, Schuuring J, van der Meulen Y, van der Graaf M, Bernsen H, Boerman R; et al. (2003). "Characterization of oligodendrogliomas using short echo time 1H MR spectroscopic imaging". NMR Biomed. 16 (1): 12–8. doi:10.1002/nbm.807. PMID 12577293.
- ↑ Image courtesy of Dr. Bruno Di Muzio. Radiopaedia (original file here). Creative Commons BY-SA-NC
- ↑ 6.0 6.1 6.2 Radiographic features of oligodendroglioma. Dr. Henry Knipe and Dr. Frank Gaillard et al. http://radiopaedia.org/articles/oligodendroglioma
- ↑ 7.0 7.1 Image courtesy of Dr. Frank Gaillard. Radiopaedia (original file here). Creative Commons BY-SA-NC
- ↑ Ceyssens S, Van Laere K, de Groot T, Goffin J, Bormans G, Mortelmans L (2006). "[11C]methionine PET, histopathology, and survival in primary brain tumors and recurrence". AJNR Am J Neuroradiol. 27 (7): 1432–7. PMID 16908552.
- ↑ Beauchesne P (2011). "Extra-neural metastases of malignant gliomas: myth or reality?". Cancers (Basel). 3 (1): 461–77. doi:10.3390/cancers3010461. PMC 3756372. PMID 24212625.
- ↑ Al-Ali F, Hendon AJ, Liepman MK, Wisniewski JL, Krinock MJ, Beckman K (2005). "Oligodendroglioma metastatic to bone marrow". AJNR Am J Neuroradiol. 26 (9): 2410–4. PMID 16219856.
- ↑ Gerrard GE, Bond MG, Jack AS (1995). "Bone marrow infiltration by a parietal lobe grade III oligodendroglioma". Clin Oncol (R Coll Radiol). 7 (5): 321–2. PMID 8580060.