Glucagonoma history and symptoms: Difference between revisions
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<gallery>Image:Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area..jpg|Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area | <gallery>Image:Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area..jpg|Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area<ref name="pmid25029913">{{cite journal| author=Wu SL, Bai JG, Xu J, Ma QY, Wu Z| title=Necrolytic migratory erythema as the first manifestation of pancreatic neuroendocrine tumor. | journal=World J Surg Oncol | year= 2014 | volume= 12 | issue= | pages= 220 | pmid=25029913 | doi=10.1186/1477-7819-12-220 | pmc=PMC4105234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25029913 }} </ref> | ||
Image:NEM1.jpg|Necrolytic migratory erythema with erosion and crust formation<ref name="pmid25152626">{{cite journal| author=Fang S, Li S, Cai T| title=Glucagonoma syndrome: a case report with focus on skin disorders. | journal=Onco Targets Ther | year= 2014 | volume= 7 | issue= | pages= 1449-53 | pmid=25152626 | doi=10.2147/OTT.S66285 | pmc=PMC4140234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25152626 }} </ref> | Image:NEM1.jpg|Necrolytic migratory erythema with erosion and crust formation<ref name="pmid25152626">{{cite journal| author=Fang S, Li S, Cai T| title=Glucagonoma syndrome: a case report with focus on skin disorders. | journal=Onco Targets Ther | year= 2014 | volume= 7 | issue= | pages= 1449-53 | pmid=25152626 | doi=10.2147/OTT.S66285 | pmc=PMC4140234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25152626 }} </ref> | ||
Image:Glucagonoma1.jpg|Skin eruptionsA) Erythema, scaling, erosions and crusts on the face B) Intense erythema with crusted erosions at perineum C) Polycyclic migratory lesions with scaling advancing borders at groin foldsD) Glossitis<ref name="pmid23259638">{{cite journal| author=Erdas E, Aste N, Pilloni L, Nicolosi A, Licheri S, Cappai A et al.| title=Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association? | journal=BMC Cancer | year= 2012 | volume= 12 | issue= | pages= 614 | pmid=23259638 | doi=10.1186/1471-2407-12-614 | pmc=PMC3543729 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23259638 }} </ref> | Image:Glucagonoma1.jpg|Skin eruptionsA) Erythema, scaling, erosions and crusts on the face B) Intense erythema with crusted erosions at perineum C) Polycyclic migratory lesions with scaling advancing borders at groin foldsD) Glossitis<ref name="pmid23259638">{{cite journal| author=Erdas E, Aste N, Pilloni L, Nicolosi A, Licheri S, Cappai A et al.| title=Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association? | journal=BMC Cancer | year= 2012 | volume= 12 | issue= | pages= 614 | pmid=23259638 | doi=10.1186/1471-2407-12-614 | pmc=PMC3543729 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23259638 }} </ref> | ||
Revision as of 18:17, 14 October 2015
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Glucagonoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Glucagonoma history and symptoms On the Web |
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American Roentgen Ray Society Images of Glucagonoma history and symptoms |
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Risk calculators and risk factors for Glucagonoma history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Symptoms of glucagonoma include necrolytic migratory erythema, cheilosis, stomatitis, diarrhea, polyuria, and polydipsia. A positive family history of multiple endocrine neoplasia type 1 may be present.
History
When evaluating a patient for glucagonoma, you should take a detailed history of the presenting symptom (onset, duration, and progression), other associated symptoms, and a thorough review of past medical history. Other specific areas of focus when obtaining the history include:
- Review of any family history of predisposing genetic disorders such as multiple endocrine neoplasia type 1.[1]
Symptoms
Common symptoms of glucagonoma include:[2]
- Necrolytic migratory erythema (NME) is a classical symptom observed in patients with glucagonoma and is present in 80% of cases. Associated NME is characterized by the spread of erythematous blisters and swelling across areas subject to greater friction and pressure, including the lower abdomen, buttocks, perineum, and groin.
- Weight loss
- Cheilosis
- Stomatitis
- Diarrhea
- Polyphagia
- Blurred vision
- Lower extremity parasthesia
Image
-
![Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area[3]](/images/6/69/Close-up_view_of_well_demarcated_erythematous_plaques%2C_with_fragile_vesicles_on_gluteal_area..jpg)
Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area[3] -
![Necrolytic migratory erythema with erosion and crust formation[4]](/images/0/08/NEM1.jpg)
Necrolytic migratory erythema with erosion and crust formation[4] -
![Skin eruptionsA) Erythema, scaling, erosions and crusts on the face B) Intense erythema with crusted erosions at perineum C) Polycyclic migratory lesions with scaling advancing borders at groin foldsD) Glossitis[5]](/images/4/44/Glucagonoma1.jpg)
Skin eruptionsA) Erythema, scaling, erosions and crusts on the face B) Intense erythema with crusted erosions at perineum C) Polycyclic migratory lesions with scaling advancing borders at groin foldsD) Glossitis[5]
![Close-up view of well demarcated erythematous plaques, with fragile vesicles on gluteal area[3]](/index.php/File:Close-up_view_of_well_demarcated_erythematous_plaques,_with_fragile_vesicles_on_gluteal_area..jpg)
![Necrolytic migratory erythema with erosion and crust formation[4]](/index.php/File:NEM1.jpg)
![Skin eruptionsA) Erythema, scaling, erosions and crusts on the face B) Intense erythema with crusted erosions at perineum C) Polycyclic migratory lesions with scaling advancing borders at groin foldsD) Glossitis[5]](/index.php/File:Glucagonoma1.jpg)
References
- ↑ Glucagonoma. U.S. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000326.htm
- ↑ Wermers RA, Fatourechi V, Wynne AG, Kvols LK, Lloyd RV (1996). "The glucagonoma syndrome. Clinical and pathologic features in 21 patients". Medicine (Baltimore). 75 (2): 53–63. PMID 8606627.
- ↑ Wu SL, Bai JG, Xu J, Ma QY, Wu Z (2014). "Necrolytic migratory erythema as the first manifestation of pancreatic neuroendocrine tumor". World J Surg Oncol. 12: 220. doi:10.1186/1477-7819-12-220. PMC 4105234. PMID 25029913.
- ↑ Fang S, Li S, Cai T (2014). "Glucagonoma syndrome: a case report with focus on skin disorders". Onco Targets Ther. 7: 1449–53. doi:10.2147/OTT.S66285. PMC 4140234. PMID 25152626.
- ↑ Erdas E, Aste N, Pilloni L, Nicolosi A, Licheri S, Cappai A; et al. (2012). "Functioning glucagonoma associated with primary hyperparathyroidism: multiple endocrine neoplasia type 1 or incidental association?". BMC Cancer. 12: 614. doi:10.1186/1471-2407-12-614. PMC 3543729. PMID 23259638.