Oligoastrocytoma pathophysiology: Difference between revisions
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*Development of oligoastrocytoma is the result of multiple [[mutation|genetic mutations]]. | *Development of oligoastrocytoma is the result of multiple [[mutation|genetic mutations]]. | ||
*Oligoastrocytomas are mixed tumors that have overlapping molecular genetics with both [[oligodendrogliomas]] and [[astrocytomas]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | *Oligoastrocytomas are mixed tumors that have overlapping molecular genetics with both [[oligodendrogliomas]] and [[astrocytomas]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | ||
*Genes associated with the pathogenesis of oligoastrocytoma include: | *Genes associated with the pathogenesis of oligoastrocytoma include:<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | ||
:*''[[Isocitrate dehydrogenase|IDH1]]'' | :*''[[Isocitrate dehydrogenase|IDH1]]'' | ||
:*[[translocation|t(1;19)(q10;p10)]] | :*[[translocation|t(1;19)(q10;p10)]] | ||
Revision as of 15:18, 16 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Pathogenesis
Genetics
- Development of oligoastrocytoma is the result of multiple genetic mutations.
- Oligoastrocytomas are mixed tumors that have overlapping molecular genetics with both oligodendrogliomas and astrocytomas.[1]
- Genes associated with the pathogenesis of oligoastrocytoma include:[1]
Gross Pathology
- On gross pathology, oligoastrocytoma is characterized by
Gallery
Microscopic Pathology
On microscopic histopathological analysis, oligoastrocytoma is characterized by:
On microscopic histopathological analysis, anaplastic oligoastrocytoma is characterized by:
Gallery
Immunohistochemistry
Oligoastrocytoma is demonstrated by positivity to tumor markers such as:[2]
References
- ↑ 1.0 1.1 Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
- ↑ IHC of oligoastrocytoma. Librepathology 2015. http://librepathology.org/wiki/index.php/Oligoastrocytoma. Accessed on October 16, 2015