Oligoastrocytoma pathophysiology: Difference between revisions
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*Development of oligoastrocytoma is the result of multiple [[mutation|genetic mutations]]. | *Development of oligoastrocytoma is the result of multiple [[mutation|genetic mutations]]. | ||
*Oligoastrocytomas are mixed tumors that have overlapping molecular genetics with both [[oligodendrogliomas]] and [[astrocytomas]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | *Oligoastrocytomas are mixed tumors that have overlapping molecular genetics with both [[oligodendrogliomas]] and [[astrocytomas]].<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref> | ||
*Genes associated with the pathogenesis of oligoastrocytoma include:<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref><ref name="pmid25143301">{{cite journal| author=Sahm F, Reuss D, Koelsche C, Capper D, Schittenhelm J, Heim S et al.| title=Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal=Acta Neuropathol | year= 2014 | volume= 128 | issue= 4 | pages= 551-9 | pmid=25143301 | doi=10.1007/s00401-014-1326-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143301 }} </ref> | *Genes associated with the pathogenesis of oligoastrocytoma include:<ref name="pmid12107116">{{cite journal| author=Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J et al.| title=Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets. | journal=Am J Pathol | year= 2002 | volume= 161 | issue= 1 | pages= 313-9 | pmid=12107116 | doi=10.1016/S0002-9440(10)64183-1 | pmc=PMC1850690 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12107116 }} </ref><ref name="pmid25143301">{{cite journal| author=Sahm F, Reuss D, Koelsche C, Capper D, Schittenhelm J, Heim S et al.| title=Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal=Acta Neuropathol | year= 2014 | volume= 128 | issue= 4 | pages= 551-9 | pmid=25143301 | doi=10.1007/s00401-014-1326-7 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143301 }} </ref><ref name="pmid18507036">{{cite journal| author=Viana-Pereira M, Lopes JM, Little S, Milanezi F, Basto D, Pardal F et al.| title=Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas. | journal=Anticancer Res | year= 2008 | volume= 28 | issue= 2A | pages= 913-20 | pmid=18507036 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18507036 }} </ref> | ||
:*''[[Isocitrate dehydrogenase|IDH1]]'' | :*''[[Isocitrate dehydrogenase|IDH1]]'' | ||
:*[[translocation|t(1;19)(q10;p10)]] | :*[[translocation|t(1;19)(q10;p10)]] |
Revision as of 15:39, 16 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Pathogenesis
- Oligoastrocytomas are mixed tumors that arises from the proliferation of both oligodendrocytes and astrocytes.[1]
- Oligoastrocytomas are low-grade (grade II) tumors. Anaplastic oligoastrocytomas are high-grade (grade III) tumors that occur in the brain.[2]
Genetics
- Development of oligoastrocytoma is the result of multiple genetic mutations.
- Oligoastrocytomas are mixed tumors that have overlapping molecular genetics with both oligodendrogliomas and astrocytomas.[3]
- Genes associated with the pathogenesis of oligoastrocytoma include:[3][4][5]
Gross Pathology
- On gross pathology, oligoastrocytoma is characterized by
Gallery
Microscopic Pathology
On microscopic histopathological analysis, oligoastrocytoma is characterized by:
On microscopic histopathological analysis, anaplastic oligoastrocytoma is characterized by:
Gallery
Immunohistochemistry
Oligoastrocytoma is demonstrated by positivity to tumor markers such as:[6]
References
- ↑ Introduction of oligodendroglioma and oligoastrocytoma. American Brain Tumor Association. http://www.abta.org/secure/oligodendrioma-oligo.pdf. Accessed on October 16, 2015
- ↑ Mixed Gliomas. Canadian ?Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/brain-spinal/brain-and-spinal-tumours/mixed-glioma/?region=on#ixzz3okGrTzyi. Accessed on October 16, 2015
- ↑ 3.0 3.1 Mueller W, Hartmann C, Hoffmann A, Lanksch W, Kiwit J, Tonn J; et al. (2002). "Genetic signature of oligoastrocytomas correlates with tumor location and denotes distinct molecular subsets". Am J Pathol. 161 (1): 313–9. doi:10.1016/S0002-9440(10)64183-1. PMC 1850690. PMID 12107116.
- ↑ Sahm F, Reuss D, Koelsche C, Capper D, Schittenhelm J, Heim S; et al. (2014). "Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma". Acta Neuropathol. 128 (4): 551–9. doi:10.1007/s00401-014-1326-7. PMID 25143301.
- ↑ Viana-Pereira M, Lopes JM, Little S, Milanezi F, Basto D, Pardal F; et al. (2008). "Analysis of EGFR overexpression, EGFR gene amplification and the EGFRvIII mutation in Portuguese high-grade gliomas". Anticancer Res. 28 (2A): 913–20. PMID 18507036.
- ↑ IHC of oligoastrocytoma. Librepathology 2015. http://librepathology.org/wiki/index.php/Oligoastrocytoma. Accessed on October 16, 2015